Karl E. Anderson, MD; Herbert L. Bonkovsky, MD; Joseph R. Bloomer, MD; Steven I. Shedlofsky, MD
Potential Financial Conflicts of Interest: Grants received: J.R. Bloomer (Ovation Pharmaceuticals).
Anderson KE, Bonkovsky HL, Bloomer JR, Shedlofsky SI. Reconstitution of Hematin for Intravenous Infusion. Ann Intern Med. 2006;144:537-538. doi: 10.7326/0003-4819-144-7-200604040-00023
Download citation file:
Published: Ann Intern Med. 2006;144(7):537-538.
TO THE EDITOR:
Background: Hemin, the preferred treatment for acute porphyrias (1), is available in the United States as lyophilized hematin (Panhematin, Ovation Pharmaceuticals, Deerfield, Illinois) and is reconstituted with sterile water just before infusion. The product package insert recommends that treatment be administered through a large arm vein or by central venous catheter to avoid phlebitis.
Many physicians and medical centers have adopted the published method of Bonkovsky and colleagues (2) for reconstituting hematin with 25% human albumin. Each albumin molecule has a single high-affinity heme binding site and additional lower affinity sites. This reconstitution method uses an equimolar amount of albumin to optimize the stability of hemin as heme albumin and to prevent formation of degradation products that lead to unwanted side effects, including phlebitis at the site of intravenous infusion and transient coagulopathy. Many health care providers have requested detailed instructions for this method of reconstituting lyophilized hematin with albumin.
Learn more about subscription options.
Register Now for a free account.
Copyright © 2016 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only