Paul E. O'Brien, MD; John B. Dixon, MBBS, PhD; Cheryl Laurie, RN; Stewart Skinner, MBBS, PhD; Joe Proietto, MBBS, PhD; John McNeil, MBBS, MSc, PhD; Boyd Strauss, MBBS, PhD; Sharon Marks, MBBS, PhD; Linda Schachter, MBBS; Leon Chapman, MBBS; Margaret Anderson, BHIM
Australian Clinical Trials Registry no. 012605000113651.
Acknowledgment: The authors acknowledge the assistance of Dr. Michael Bailey with the statistical analyses performed in the study.
Grant Support: By the Department of Surgery, Monash University. INAMED Health, manufacturer of the LAP-BAND System; Novartis, manufacturer of Optifast; and U.S. Surgical Corp., manufacturer of disposable laparoscopic instruments, provided the equipment devices or products.
Potential Financial Conflicts of Interest: Consultancies: J.B. Dixon (INAMED Health, Novartis), S. Marks (Novartis); Grants received: P.E. O'Brien (INAMED Health, Novartis, U.S. Surgical Corp.), J.B. Dixon (INAMED Health, Novartis).
Requests for Single Reprints: Professor Paul O'Brien, MD, Centre for Obesity Research and Education, Monash University Medical School, The Alfred Hospital, Melbourne 3004, Australia; e-mail, email@example.com.
Current Author Addresses: Drs. O'Brien, Dixon, Skinner, and Schachter and Ms. Laurie and Ms. Anderson: Centre for Obesity Research and Education, Monash University Medical School, The Alfred Hospital, Melbourne 3004, Australia.
Dr. Proietto: University of Melbourne Department of Medicine, Austin Hospital, Heidelberg, Victoria 3081, Australia.
Dr. McNeil: Monash University Department of Epidemiology and Public Health, The Alfred Hospital, Melbourne 3004, Australia.
Drs. Strauss and Marks: Monash University Department of Medicine, Monash Medical Centre, Clayton, Victoria 3168, Australia.
Dr. Chapman: International Diabetes Institute, 250 Kooyong Road, Caulfield, Victoria 3162, Australia.
Author Contributions: Conception and design: P.E. O'Brien, J.B. Dixon, J. Proietto, J. McNeil, B. Strauss, S. Marks, L. Chapman.
Analysis and interpretation of the data: P.E. O'Brien, J.B. Dixon, S. Skinner, J. Proietto, J. McNeil, L. Schachter, L. Chapman.
Drafting of the article: P.E. O'Brien, S. Skinner, L. Schachter, L. Chapman.
Critical revision of the article for important intellectual content: J.B. Dixon, J. Proietto, J. McNeil, B. Strauss, S. Marks, L. Schachter, L. Chapman.
Final approval of the article: P.E. O'Brien, J.B. Dixon, J. Proietto, J. McNeil, L. Schachter, L. Chapman.
Provision of study materials or patients: P.E. O'Brien, J.B. Dixon, S. Skinner, B. Strauss, L. Schachter, L. Chapman.
Statistical expertise: J.B. Dixon.
Obtaining of funding: P.E. O'Brien, J.B. Dixon.
Administrative, technical, or logistic support: P.E. O'Brien, J.B. Dixon, C. Laurie, M. Anderson.
Collection and assembly of data: P.E. O'Brien, J.B. Dixon, C. Laurie, L. Chapman, M. Anderson.
O'Brien PE, Dixon JB, Laurie C, Skinner S, Proietto J, McNeil J, et al. Treatment of Mild to Moderate Obesity with Laparoscopic Adjustable Gastric Banding or an Intensive Medical Program: A Randomized Trial. Ann Intern Med. 2006;144:625-633. doi: 10.7326/0003-4819-144-9-200605020-00005
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Published: Ann Intern Med. 2006;144(9):625-633.
The development of a safe and effective treatment for obesity is a leading challenge in health care today. Obesity is an increasing health problem across the world with a prevalence of more than 20% among the adult population in Western countries and more than 30% in the United States (1, 2). The increasing prevalence is associated with a parallel increase of several obesity-related diseases, in particular, the diseases of the metabolic syndrome (3, 4), which include type 2 diabetes, hypertension, and dyslipidemia, and are linked to nonalcoholic steatohepatitis, obstructive sleep apnea, and the polycystic ovary syndrome.
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