Rob M. van Dam, PhD; Walter C. Willett, MD; JoAnn E. Manson, MD; Frank B. Hu, MD
Acknowledgment: The authors thank the participants of the Nurses' Health Study II for their continued cooperation.
Grant Support: By the National Institutes of Health (grant CA50385).
Potential Financial Conflicts of Interest: None disclosed.
Corresponding Author: Rob M. van Dam, Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Building II, Boston, MA 02115; e-mail, firstname.lastname@example.org.
Current Author Addresses: Drs. van Dam, Willett, and Hu: Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Building II, Boston, MA 02115.
Dr. Manson: Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Avenue East, Third Floor, Boston, MA 02215.
Author Contributions: Conception and design: R.M. van Dam, W.C. Willett, J.E. Manson, F.B. Hu.
Analysis and interpretation of the data: R.M. van Dam, J.E. Manson, F.B. Hu.
Drafting of the article: R.M. van Dam.
Critical revision of the article for important intellectual content: R.M. van Dam, W.C. Willett, J.E. Manson, F.B. Hu.
Final approval of the article: R.M. van Dam, W.C. Willett, J.E. Manson, F.B. Hu.
Statistical expertise: R.M. van Dam, J.E. Manson, F.B. Hu.
Obtaining of funding: W.C. Willett, F.B. Hu.
Administrative, technical, or logistic support: J.E. Manson, F.B. Hu.
Collection and assembly of data: W.C. Willett.
van Dam RM, Willett WC, Manson JE, Hu FB. The Relationship between Overweight in Adolescence and Premature Death in Women. Ann Intern Med. 2006;145:91-97. doi: 10.7326/0003-4819-145-2-200607180-00006
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Published: Ann Intern Med. 2006;145(2):91-97.
The prevalence of overweight and obesity is increasing in the United States and worldwide in children and adults (1-3). Being overweight during childhood and adolescence can have detrimental consequences on psychological and social factors, cardiovascular risk factors, and risk for chronic diseases and is associated with a higher prevalence of obesity in adulthood (4). Several studies have examined whether adiposity in childhood and adolescence is also related to premature death in adulthood (5-15). However, these studies largely concerned older birth cohorts that included few participants who were overweight during youth and few who never smoked (6, 8-10, 12-14). In addition, data from more recent studies are needed to address the proposition that the impact of obesity on death may have decreased recently because of advances in public health and medical care (16).
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