John Hornberger, MD, MS; Katherine Robertus, MPH
Potential Financial Conflicts of Interest: None disclosed.
Requests for Single Reprints: John Hornberger, MD, MS, Acumen LLC, 500 Airport Boulevard, Suite 365, Burlingame, CA 94010; e-mail, email@example.com.
Current Author Addresses: Dr. Hornberger and Ms. Robertus: Acumen LLC, 500 Airport Boulevard, Suite 365, Burlingame, CA 94010.
Author Contributions: Conception and design: J. Hornberger.
Analysis and interpretation of the data: J. Hornberger, K. Robertus.
Drafting of the article: J. Hornberger.
Critical revision of the article for important intellectual content: J. Hornberger, K. Robertus.
Final approval of the article: J. Hornberger, K. Robertus.
Provision of study materials or patients: J. Hornberger.
Statistical expertise: J. Hornberger, K. Robertus.
Obtaining of funding: J. Hornberger.
Administrative, technical, or logistic support: J. Hornberger.
Collection and assembly of data: J. Hornberger, K. Robertus.
Hornberger J, Robertus K. Cost-Effectiveness of a Vaccine To Prevent Herpes Zoster and Postherpetic Neuralgia in Older Adults. Ann Intern Med. 2006;145:317-325. doi: 10.7326/0003-4819-145-5-200609050-00004
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Published: Ann Intern Med. 2006;145(5):317-325.
Herpes zoster results from reactivation of latent varicella-zoster virus (VZV) infection residing in sensory ganglia. The disease presents as a clinical syndrome characterized by a painful vesicular eruption (1). In the United States, herpes zoster affects about 300 000 to 600 000 persons annually (2). Sequelae occur in about 12% of cases and include postherpetic neuralgia (PHN) (7.9%), bacterial skin infections (2.3%), ocular complications (such as uveitis and keratitis) (1.6%), motor neuropathy (0.9%), meningitis (0.5%), and herpes simplex virus oticus (0.2%) (3). Herpes zoster incidence is approximately 2.2 cases per 1000 person-years and peaks at 14.2 cases per 1000 person-years for individuals older than age 75 years (4-5).
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Infectious Disease, Vaccines/Immunization, Prevention/Screening.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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