Hiroyasu Iso, MD
Potential Financial Conflicts of Interest: None disclosed.
Iso H.; Green Tea, Coffee, and Diabetes. Ann Intern Med. 2006;145:634-635. doi: 10.7326/0003-4819-145-8-200610170-00019
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Published: Ann Intern Med. 2006;145(8):634-635.
We thank the correspondents for their interest in our study. In response to Dr. Chen's queries, there was no difference in mean BMI between respondents and nonrespondents in each category of green tea and coffee consumption, except for the category of at least 6 cups of green tea per day in men (22.6 kg/m2 vs. 22.9 kg/m2; P = 0.02) and the category of 1 to 6 cups of coffee per week in men (22.6 kg/m2 vs. 23.0 kg/m2; P = 0.008) and women (22.8 kg/m2 vs. 23.2 kg/m2; P = 0.005), where no protective effect was found in our Table 3. Thus, the difference in BMI in these categories of green tea and coffee consumption did not explain follow-up bias. Even after we adjusted for educational levels (≤15, 16 to 18, and ≥19 years of education), the multivariable odds ratios for diabetes for frequent drinkers of green tea (≥6 cups/d) and coffee (≥3 cups/d) and the highest quintile of caffeine intake did not change materially: 0.68 (95% CI, 0.48 to 0.96; P = 0.247 for trend), 0.59 (CI, 0.38 to 0.92; P = 0.037 for trend), and 0.69 (CI, 0.48 to 0.97; P = 0.027 for trend), respectively. For the overweight men, the multivariable odds ratio for the highest quintile of caffeine intake was 0.36 (CI, 0.13 to 0.99; P = 0.026 for trend). We could not confirm the protective effect of green tea and coffee against death from diabetes because only 33 deaths were caused by diabetes (International Classification of Diseases, 10th revision, codes E10 to 14).
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