Dan M. Roden, MD; Russ B. Altman, MD, PhD; Neal L. Benowitz, MD; David A. Flockhart, MD, PhD; Kathleen M. Giacomini, PhD; Julie A. Johnson, PharmD; Ronald M. Krauss, MD; Howard L. McLeod, PharmD; Mark J. Ratain, MD; Mary V. Relling, PharmD; Huijun Z. Ring, PhD; Alan R. Shuldiner, MD; Richard M. Weinshilboum, MD; Scott T. Weiss, MD; Pharmacogenetics Research Network
Acknowledgments: The authors thank Rochelle Long, Dina Paltoo, and Eileen Dolan for their comments on earlier versions of the manuscript.
Grant Support: Sites in the Pharmacogenetics Research Network are supported by the following U01 awards: GM61373, GM61390, GM74492, HL69757, GM61393, GM63340, HL65962, GM74518, GM61388, DA20830, and HL65899. The Pharmacogenetics and Pharmacogenomics Knowledge Base created by the network is housed at http://www.pharmgkb.org and is supported by U01 GM61374.
Potential Financial Conflicts of Interest:Consultancies: D.M. Roden (GlaxoSmithKline, Pfizer Inc., AstraZeneca, Abbott Laboratories, Novartis, 1st Genetic Trust), R.M. Krauss (Abbott Laboratories, AstraZeneca, Bristol-Myers Squibb, Merck & Co. Inc., Pfizer Inc., International Dairy Foods Association), M.J. Ratain (Prometheus, Genzyme Corp., Genentech), R.M. Weinshilboum (National Institutes of Health); S.T. Weiss (Glaxo-Wellcome, Roche Pharmaceuticals, Millennium Pharmaceuticals, Genetech, Schering-Plough, Variagenics, Genome Therapeutics, Merck Frost); Honoraria: D.M. Roden (GlaxoSmithKline, Pfizer, Inc., AstraZeneca, Abbott Laboratories, Novartis, 1st Genetic Trust), Dr. Krauss (Kos Pharmaceuticals, Pfizer); Stock ownership or options (other than mutual funds): M.J. Ratain (Variagenics, Nuvelo, Applera); Grants received: D.M. Roden (1st Genetic Trust), R.M. Krauss (King, Merck & Co. Inc., Schering-Plough, Pfizer Inc.), H.L.M. Leod (National Institutes of Health), M.J. Ratain (National Institutes of Health), R.M. Weinshilboum (Eli Lilly Inc.); S.T. Weiss (Glaxo Wellcome, AstraZeneca, Pfizer Inc.); Grants pending: D.M. Roden (GlaxoSmithKline), M.J. Ratain (National Institutes of Health); Patents received: M.J. Ratain (National Institutes of Health), M.V. Relling (National Institutes of Health); Patents pending: M.J. Ratain (National Institutes of Health); Royalties: D.M. Roden (Genaissance), M.J. Ratain (National Institutes of Health).
Requests for Single Reprints: Dan M. Roden, MD, Vanderbilt University School of Medicine, 2215B Garland Avenue, Room 1285B, MRB4, Nashville, TN 37232; e-mail, firstname.lastname@example.org.
Current Author Addresses: Dr. Roden: Vanderbilt University School of Medicine, 2215B Garland Avenue, Room 1285B, MRB4, Nashville, TN 37232-0575.
Dr. Altman: Department of Genetics, Stanford University Medical Center, 300 Pasteur Drive, Lane L301, Mail Code 5120, Stanford, CA 94305-5120.
Dr. Benowitz: University of California, San Francisco, Box 1220, 1001 Potrero Avenue, San Francisco General Hospital, 30 3316, San Francisco, CA 94143-1220.
Dr. Flockhart: Indiana University, 1001 West 10th Street, W-7123, Indianapolis, IN 46202.
Dr. Giacomini: University of California, San Francisco, 1550 4th Street, Mission Bay GD 584, San Francisco, CA 94143-2911.
Dr. Johnson: University of Florida, 1600 Southwest Archer Road, Room PG-22, Gainesville, FL 32610-0486.
Dr. Krauss: Children's Hospital Oakland Research Institute, 5700 Martin Luther King Jr. Way, Oakland, CA 94609.
Dr. McLeod: University of North Carolina, Chapel Hill, Campus Box 7360, 3203 Kerr Hall, Chapel Hill, NC 27599-7360.
Dr. Ratain: University of Chicago, 5841 South Maryland Avenue, MC 2115, Chicago, IL 60637-1470.
Dr. Relling: St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis, TN 38105.
Dr. Ring: SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025.
Dr. Shuldiner: Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, 660 West Redwood Street, HH-Room 494, Baltimore, MD 21201.
Dr. Weinshilboum: Mayo Clinic, 200 First Street SW, Rochester, MN 55905.
Dr. Weiss: Channing Laboratory, Brigham & Women's Hospital, 181 Longwood Avenue, Boston, MA 02115.
Roden DM, Altman RB, Benowitz NL, Flockhart DA, Giacomini KM, Johnson JA, et al. Pharmacogenomics: Challenges and Opportunities. Ann Intern Med. 2006;145:749-757. doi: 10.7326/0003-4819-145-10-200611210-00007
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Published: Ann Intern Med. 2006;145(10):749-757.
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