Nicolai Lohse, MD, PhD; Ann-Brit Eg Hansen, MD; Gitte Pedersen, MD, PhD; Gitte Kronborg, MD, DMSc; Jan Gerstoft, MD, DMSc; Henrik Toft Sørensen, MD, PhD, DMSc; Michael Væth, PhD; Niels Obel, MD, DrSci, DMSc
Acknowledgments: The authors thank the staff of their clinical departments for their continuous support and enthusiasm.
Grant Support: The Danish HIV Cohort study receives funding from the Danish AIDS Foundation, Odense University Hospital, Preben and Anna Simonsen's Foundation, the Foundation of the Danish Association of Pharmacists, and the Clinical Institute at the University of Southern Denmark.
Potential Financial Conflicts of Interest: Consultancies: J. Gerstoft (Roche, Glaxo, Abbott, Boehringer Ingelheim, Merck Sharp & Dohme, Swedish-Orphan Drugs); Honoraria: J. Gerstoft (Roche, Glaxo, Abbott, Boehringer Ingelheim, MSD, Swedish-Orphan Drugs); Grants received: N. Obel (Roche, Bristol-Meyers Squibb, Merck Sharp & Dohme, GlaxoSmithKline, Abbott, Boehringer Ingelheim, Janssen-Cilag, Swedish-Orphan Drugs).
Requests for Single Reprints: Nicolai Lohse, MD, PhD, Department of Infectious Diseases, Odense University Hospital, Sdr. Boulevard 29, DK-5000 Odense C, Denmark; e-mail, email@example.com.
Current Author Addresses: Drs. Lohse, Hansen, and Obul: Department of Infectious Diseases, Odense University Hospital, Sdr. Boulevard 29, DK-5000 Odense C, Denmark.
Dr. Pedersen: Department of Infectious Diseases, Aalborg University Hospital, DK-9000 Aalborg, Denmark.
Dr. Kronborg: Department of Infectious Diseases, Hvidovre Hospital, DK-2650 Hvidovre, Denmark.
Dr. Gerstoft, Department of Infectious Diseases, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen Ø, Denmark.
Dr. Sørensen: Department of Clinical Epidemiology, Århus University Hospital, Ole Worms Allé 1150, DK-8000 Århus C, Århus, Denmark.
Dr. Væth: Department of Biostatistics, University of Århus, DK-8000 Århus C, Denmark.
Author Contributions: Conception and design: N. Lohse, A.-B.E. Hansen, H.T. Sørensen, N. Obel.
Analysis and interpretation of the data: N. Lohse, H.T. Sørensen, M. Væth, N. Obel.
Drafting of the article: N. Lohse.
Critical revision of the article for important intellectual content: N. Lohse, A.-B.E. Hansen, G. Pedersen, G. Kronborg, J. Gerstoft, H.T. Sørensen, M. Væth, N. Obel.
Final approval of the article: N. Lohse, A.-B.E. Hansen, G. Pedersen, G. Kronborg, J. Gerstoft, H.T. Sørensen, M. Væth, N. Obel.
Provision of study materials or patients: G. Pedersen, G. Kronborg, J. Gerstoft, N. Obel.
Statistical expertise: N. Lohse, M. Væth.
Obtaining of funding: N. Obel.
Administrative, technical, or logistic support: N. Lohse, N. Obel.
Collection and assembly of data: N. Lohse, A.-B.E. Hansen, G. Kronborg, J. Gerstoft, N. Obel.
Lohse N., Hansen A., Pedersen G., Kronborg G., Gerstoft J., Sørensen H., Væth M., Obel N.; Survival of Persons with and without HIV Infection in Denmark, 1995–2005. Ann Intern Med. 2007;146:87-95. doi: 10.7326/0003-4819-146-2-200701160-00003
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Published: Ann Intern Med. 2007;146(2):87-95.
Knowing the expected survival of HIV-infected patients is of major public health interest. Mortality rates have decreased substantially in recent years as a result of improved effectiveness of highly active antiretroviral therapy (HAART) (1). Studies comparing mortality rates for HIV-infected persons with age- and sex-specific mortality rates for the general population (2–5) have reported 3- to 10-fold increase in successfully treated patients. The relative mortality rate, however, is highly dependent on the age distribution of the study sample and does not in itself answer questions about survival. We therefore aimed to estimate median survival and age-specific mortality rates for an entire HIV-infected population compared with a cohort from the general population. Persons with HIV infection were followed from before initiation of HAART and included those with such predictors of lower survival as poor response to therapy, AIDS diagnosis, low CD4 count, high viral load, and poor adherence to treatment (6, 7). Linking data from the population-based Danish HIV Cohort Study (DHCS) (8) and the Danish Civil Registration System (CRS) (9, 10) allowed us to use product-limit methods that are analogous to the period life tables used by national authorities for estimating median survival (11).
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Infectious Disease, HIV.
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