Alan T. Mulgrew, MB; Nurit Fox, MSc, CCRP; Najib T. Ayas, MD, MPH; C. Frank Ryan, MB
ClinicalTrials.gov identifier: NCT00254059.
Acknowledgments: The authors thank their colleagues, staff, and patients of the University of British Columbia Hospital Sleep Disorders Program for their help in the conduct of this study. They also thank Drs. Penny Brasher and Michael Schulzer for their help with the statistical analysis.
Grant Support: By way of a Grant-in-Aid from ResMed Corp., Poway, California, and Vitalaire Canada Inc., Mississauga, Ontario, Canada; and a Michael Smith Foundation for Health Research Infrastructure Grant (Sleep-Disordered Breathing). One Remmers Sleep Recorder (formerly SnoreSat, Sagatech Electronics Inc., Calgary, Alberta, Canada) was provided on loan for the duration of the study. Dr. Mulgrew is supported by a BC Lung Fellowship and by the CIHR/HSFC IMPACT training program. Dr. Ayas is supported by a Michael Smith Foundation for Health Research Scholar Award, a CIHR/BC Lung Association New Investigator Award, and a Departmental Scholar Award from the University of British Columbia.
Potential Financial Conflicts of Interest: Grants received: N.T. Ayas (Respironics Inc.), C.F. Ryan (ResMed Corp., Vitalaire Canada, Inc.).
Requests for Single Reprints: Frank Ryan, MB, The Lung Centre, 7th Floor, Diamond Health Care Centre, 2775 Laurel Street, Vancouver, British Columbia, V5Z 1M9, Canada; e-mail, firstname.lastname@example.org.
Current Author Addresses: Drs. Mulgrew, Fox, Ayas, and Ryan: The Lung Centre, 7th Floor, Diamond Health Care Centre, 2775 Laurel Street, Vancouver, British Columbia V5Z 1M9, Canada.
Author Contributions: Conception and design: C.F. Ryan.
Analysis and interpretation of the data: A.T. Mulgrew, C.F. Ryan.
Drafting of the article: A.T. Mulgrew, C.F. Ryan.
Critical revision of the article for important intellectual content: A.T. Mulgrew, N.T. Ayas.
Final approval of the article: A.T. Mulgrew, N. Fox, N.T. Ayas, C.F. Ryan.
Provision of study materials or patients: N.T. Ayas, C.F. Ryan.
Statistical expertise: A.T. Mulgrew, N.T. Ayas.
Obtaining of funding: C.F. Ryan.
Administrative, technical, or logistic support: A.T. Mulgrew, N. Fox.
Collection and assembly of data: N. Fox.
Mulgrew AT, Fox N, Ayas NT, Ryan CF. Diagnosis and Initial Management of Obstructive Sleep Apnea without Polysomnography: A Randomized Validation Study. Ann Intern Med. 2007;146:157-166. doi: 10.7326/0003-4819-146-3-200702060-00004
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Published: Ann Intern Med. 2007;146(3):157-166.
Symptomatic obstructive sleep apnea is a common, underdiagnosed condition that occurs in 4% of men and in 2% of women (1). Patients with obstructive sleep apnea have considerable comorbid conditions, including excessive daytime sleepiness; concentration difficulties; and an increased risk for motor vehicle accidents, hypertension (2), coronary artery disease, and strokes. Obstructive sleep apnea may result in a systemic inflammatory state that predisposes the patient to cardiac and cerebrovascular conditions (3). Continuous positive airway pressure (CPAP) is an effective treatment that is commonly prescribed for symptomatic patients with obstructive sleep apnea: It is cost-effective (4) and reduces daytime sleepiness, rates of motor vehicle accidents, and blood pressure.
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Pulmonary/Critical Care, Sleep Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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