Joseph J. Gallo, MD, MPH; Hillary R. Bogner, MD, MSCE; Knashawn H. Morales, ScD; Edward P. Post, MD, PhD; Julia Y. Lin, PhD; Martha L. Bruce, PhD, MPH
Grant Support: The mortality follow-up of PROSPECT participants was funded by the National Institute of Mental Health (principal investigator, Joseph J. Gallo, MD, MPH [R01 MH065539]). The PROSPECT was a collaborative research study funded by the National Institute of Mental Health. The 3 groups included in the funded study were the Advanced Centers for Intervention and Services Research of Cornell University (coordinating center; principal investigator, George S. Alexopoulos, MD, and co-principal investigators, Martha L. Bruce, PhD, MPH, and Herbert C. Schulberg, PhD [R01 MH59366, P30 MH68638]), University of Pennsylvania (principal investigator, Ira Katz, MD, PhD, and co-principal investigators, Thomas Ten Have, PhD, and Gregory K. Brown, PhD [R01 MH59380, P30 MH52129]), and University of Pittsburgh (principal investigator, Charles F. Reynolds III, MD, and co-principal investigator, Benoit H. Mulsant, MD [R01 MH59381, P30 MH52247]). Additional small grants came from Forest Laboratories and the John D. Hartford Foundation. Participation of Drs. Gallo, Bogner, Post, and Bruce was also supported by National Institute of Mental Health awards (K24 MH070407, K23 MH67671, K23 MH01879, and K02 MH01634). Dr. Bogner is a Robert Wood Johnson Foundation Generalist Physician Faculty Scholar (2004 to 2008).
Potential Financial Conflicts of Interest: None disclosed.
Requests for Single Reprints: Joseph J. Gallo MD, MPH, Department of Family Medicine and Community Health, School of Medicine, University of Pennsylvania, 3400 Spruce Street, 2 Gates Building, Philadelphia, PA 19104; e-mail, email@example.com.
Current Author Addresses: Drs. Gallo and Bogner: Department of Family Medicine and Community Health, School of Medicine, University of Pennsylvania, 3400 Spruce Street, 2 Gates Building, Philadelphia, PA 19104.
Dr. Morales: Center for Clinical Epidemiology and Biostatistics, School of Medicine, University of Pennsylvania, 423 Guardian Drive, 626 Blockley Hall, Philadelphia, PA 19104.
Dr. Post: University of Michigan and Ann Arbor Veterans Affairs Healthcare System, Health Services Research & Development (11H), 2215 Fuller Road, Ann Arbor, MI 48105.
Dr. Lin: Cambridge Health Alliance, 120 Beacon Street, Somerville, MA 02143.
Dr. Bruce: Cornell University, 21 Bloomingdale Road, White Plains, NY 10605.
Author Contributions: Conception and design: J.J. Gallo, H.R. Bogner, M.L. Bruce.
Analysis and interpretation of the data: J.J. Gallo, H.R. Bogner, K.H. Morales, J.Y. Lin, M.L. Bruce.
Drafting of the article: J.J. Gallo, H.R. Bogner, K.H. Morales, M.L. Bruce.
Critical revision of the article for important intellectual content: J.J. Gallo, H.R. Bogner, K.H. Morales, E.P. Post, M.L. Bruce.
Final approval of the article: J.J. Gallo, H.R. Bogner, K.H. Morales, E.P. Post, M.L. Bruce.
Statistical expertise: K.H. Morales, E.P. Post.
Obtaining of funding: J.J. Gallo, E.P. Post, M.L. Bruce.
Administrative, technical, or logistic support: E.P. Post.
Collection and assembly of data: J.J. Gallo, E.P. Post, M.L. Bruce.
Gallo JJ, Bogner HR, Morales KH, Post EP, Lin JY, Bruce ML. The Effect of a Primary Care Practice–Based Depression Intervention on Mortality in Older Adults: A Randomized Trial. Ann Intern Med. 2007;146:689-698. doi: 10.7326/0003-4819-146-10-200705150-00002
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Published: Ann Intern Med. 2007;146(10):689-698.
Persons with depression are more likely to die, but studies have not shown that treatment of depression reduces mortality.
Investigators observed a 45% reduction in the hazard of death among patients with major depression cared for in primary care practices that were randomly assigned to a depression care management program.
The reduction in deaths occurred almost exclusively among patients who died of cancer. The mechanism for the effect is unclear and might be due to misclassification of cause of death or vital status.
A practice-level depression care management program seemed to reduce deaths due to cancer in older patients with major depression.
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Geriatric Medicine, Prevention/Screening.
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