Sharda Patra, MS; Ashish Kumar, MD, DM; Shubha Sagar Trivedi, MS; Manju Puri, MS; Shiv Kumar Sarin, MD, DM
Note: This research was presented in the Plenary Award Session of the 14th Annual Conference of Asia-Pacific Association for the Study of Liver, Bali, Indonesia, 15–22 August 2005.
Potential Financial Conflicts of Interest: None disclosed.
Requests for Single Reprints: Shiv Kumar Sarin, MD, DM, Department of Gastroenterology, G.B. Pant Hospital, Room 201, Academic Block, New Delhi 110 002, India; e-mail, email@example.com.
Current Author Addresses: Ms. Patra, Ms. Trivedi, and Ms. Puri: Lady Hardinge Medical College, New Delhi 110 001, India.
Dr. Kumar: Department of Gastroenterology, G.B. Pant Hospital, New Delhi 110 002, India.
Dr. Sarin: Department of Gastroenterology, G.B. Pant Hospital, Room 201, Academic Block, New Delhi 110 002, India.
Author Contributions: Conception and design: S. Patra, A. Kumar, S.S. Trivedi, M. Puri, S.K. Sarin.
Analysis and interpretation of the data: S. Patra, A. Kumar, M. Puri, S.K. Sarin.
Drafting of the article: S. Patra, A. Kumar, M. Puri, S.K. Sarin.
Critical revision of the article for important intellectual content: S. Patra, A. Kumar, S.S. Trivedi, S.K. Sarin.
Final approval of the article: S. Patra, A. Kumar, S.K. Sarin.
Provision of study materials or patients: S. Patra, A. Kumar, S.S. Trivedi, M. Puri, S.K. Sarin.
Administrative, technical or logistic support: A Kumar, S.S. Trivedi, M. Puri, S.K. Sarin.
Collection and assembly of data: S. Patra, A. Kumar, S.K. Sarin.
Patra S, Kumar A, Trivedi SS, Puri M, Sarin SK. Maternal and Fetal Outcomes in Pregnant Women with Acute Hepatitis E Virus Infection. Ann Intern Med. 2007;147:28-33. doi: 10.7326/0003-4819-147-1-200707030-00005
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Published: Ann Intern Med. 2007;147(1):28-33.
Hepatitis E virus (HEV) is a single-stranded RNA virus that causes large-scale epidemics and sporadic cases of acute viral hepatitis in developing countries (1, 2). Infection with HEV also poses a significant risk for acute viral hepatitis to travelers in endemic areas (3). The main source of transmission of HEV is contaminated drinking water (4, 5). In men and nonpregnant women, the disease is usually self-limited and has a low case-fatality rate (<0.1%) (6). However in pregnant women, HEV infection is more severe, often leading to fulminant hepatic failure and death in up to 15% to 20% of cases. This high mortality rate was first reported in an epidemic setting in the early 1980s (7) and was reported again in a sporadic setting in 2003 (8).
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