Francisco M. Marty, MD; Sophia Koo, MD; Julie Bryar, BA; Lindsey R. Baden, MD
Potential Financial Conflicts of Interest: None disclosed.
Marty FM, Koo S, Bryar J, Baden LR. (1→3)β-d-Glucan Assay Positivity in Patients with Pneumocystis (carinii) jiroveci Pneumonia. Ann Intern Med. 2007;147:70-72. doi: 10.7326/0003-4819-147-1-200707030-00018
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Published: Ann Intern Med. 2007;147(1):70-72.
Background: Measurement of serum (1→3)β-d-glucan (β-glucan) is now available in the United States as a diagnostic aid for invasive fungal infections in high-risk patients (1, 2). β-Glucan is a cell-wall component of most pathogenic fungi, including Pneumocystis jiroveci (formerly P. carinii) (3). Serum β-glucan positivity in patients with Pneumocystis (carinii) jiroveci pneumonia (PCP) has been reported in Japan (4, 5). Whether the assay licensed in the United States (Fungitell, Associates of Cape Cod, Falmouth, Massachusetts) is reactive in patients with PCP is unknown (1, 2).
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