Jennifer F. Wilson
Wilson J.; Irritable Bowel Syndrome. Ann Intern Med. 2007;147:ITC7-1. doi: 10.7326/0003-4819-147-1-200707030-01007
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Published: Ann Intern Med. 2007;147(1):ITC7-1.
Irritable bowel syndrome (IBS) is a common but poorly understood disorder that interferes with normal colon function, resulting in abdominal pain, bloating, constipation, and diarrhea. No specific biological biomarker, physiologic abnormality, or anatomical defect has been discovered. Psychosocial stress may exacerbate symptoms.
IBS is 1 of 28 adult and 17 pediatric functional gastrointestinal disorders. These disorders are symptom-based and not explained by other pathologically defined diseases. IBS appears to be linked to motor and sensory physiology and brain-gut interaction (1). Emerging theories suggest that alteration of intestinal bacteria may also play a role in the condition. IBS affects as many as 1 in 5 U.S. adults, occurs more often in women than in men, and begins before the age of 35 in about half of all people who develop the disorder. IBS is recognized worldwide, but prevalence varies geographically.
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Gastroenterology/Hepatology, Irritable Bowel Syndrome.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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