Wee-Shian Chan, MD, MSc; Sanjeev Chunilal, MB, ChB; Agnes Lee, MD, MSc; Mark Crowther, MD, MSc; Marc Rodger, MD, MSc; Jeffrey S. Ginsberg, MD
Acknowledgment: The authors thank Agen Biomedical for providing the SimpliRED assay kits.
Grant Support: Partial funding was provided over 2 years by the Heart and Stroke Foundation of Ontario (grant NA 5048) to recruit patients into the study. Dr. Ginsberg is a recipient of a Career Investigator Award from the Heart and Stroke Foundation of Ontario.
Potential Financial Conflicts of Interest: Grants received: S. Chunilal (Agen Biomedical).
Requests for Single Reprints: Wee-Shian Chan, MD, MSc, Department of Medicine, Women's College Hospital, 76 Grenville Street, Toronto, Ontario M5G 1B2, Canada; e-mail, email@example.com.
Current Author Addresses: Dr. Chan: Department of Medicine, Women's College Hospital, 76 Grenville Street, Toronto, Ontario M5G 1B2, Canada.
Dr. Chunilal: North Shore Hospital, PO Box 93-503, Takapuna, Auckland, New Zealand.
Dr. Lee: Henderson General Division, Hamilton Health Sciences Corp., 711 Concession Street, Hamilton, Ontario L8V 1C3, Canada.
Dr. Crowther: St. Joseph's Hospital, Room L 208-4, 50 Charlton Avenue East, Hamilton, Ontario L8N 4A6, Canada.
Dr. Rodger: Division of Hematology, The Ottawa Hospital General Campus, 501 Smyth Road, Ottawa, Ontario K1H 8L6, Canada.
Dr. Ginsberg: McMaster University Medical Centre, 1200 Main Street West, HSC-3W11, Hamilton, Ontario L8N 3Z5, Canada.
Author Contributions: Conception and design: W.S. Chan, S. Chunilal, A. Lee, M. Rodger.
Analysis and interpretation of the data: W.S. Chan, S. Chunilal, A. Lee, M. Rodger.
Drafting of the article: W.S. Chan, J.S. Ginsberg.
Critical revision of the article for important intellectual content: W.S. Chan, A. Lee, M. Rodger, J.S. Ginsberg.
Final approval of the article: W.S. Chan, A. Lee, M. Rodger, J.S. Ginsberg.
Provision of study materials or patients: W.S. Chan, S. Chunilal, A. Lee, M. Crowther, M. Rodger.
Statistical expertise: S. Chunilal, M. Rodger.
Obtaining of funding: W.S. Chan, S. Chunilal, M. Crowther, M. Rodger.
Administrative, technical, or logistic support: M. Rodger.
Collection and assembly of data: W.S. Chan, M. Crowther, M. Rodger.
Chan W, Chunilal S, Lee A, Crowther M, Rodger M, Ginsberg JS. A Red Blood Cell Agglutination d-Dimer Test to Exclude Deep Venous Thrombosis in Pregnancy. Ann Intern Med. 2007;147:165-170. doi: 10.7326/0003-4819-147-3-200708070-00005
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Published: Ann Intern Med. 2007;147(3):165-170.
Venous thromboembolism (VTE) remains a major cause of maternal morbidity and mortality in developed countries (1–5), and deep venous thrombosis (DVT) is its most common manifestation. Although the overall incidence of VTE among pregnant women is low—fewer than 1 per 1000 pregnancies (5, 6)—this represents a 3- to 4-fold increased risk for VTE compared with age-matched nonpregnant women. As in nonpregnant women, clinical assessment alone is inaccurate for the diagnosis of DVT in symptomatic pregnant patients. The diagnosis of DVT in pregnant patients is further confounded by the frequent occurrence of nonthrombotic causes of leg swelling and pain and the lack of studies evaluating the accuracy of diagnostic testing for DVT.
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Pulmonary/Critical Care, Venous Thromboembolism, Pulmonary Embolism.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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