Saverio Stranges, MD, PhD; James R. Marshall, PhD; Raj Natarajan, MS; Richard P. Donahue, PhD; Maurizio Trevisan, MD; Gerald F. Combs, PhD; Francesco P. Cappuccio, MD; Antonio Ceriello, MD; Mary E. Reid, PhD
Stranges S, Marshall JR, Natarajan R, Donahue RP, Trevisan M, Combs GF, et al. Effects of Long-Term Selenium Supplementation on the Incidence of Type 2 Diabetes: A Randomized Trial. Ann Intern Med. 2007;147:217-223. doi: 10.7326/0003-4819-147-4-200708210-00175
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Published: Ann Intern Med. 2007;147(4):217-223.
Research suggests that selenium supplements may improve glucose metabolism.
The investigators examined the incidence of type 2 diabetes among participants in a clinical trial designed to assess the effects of selenium supplementation on skin cancer. Participants randomly assigned to receive selenium were more likely to develop type 2 diabetes than were those assigned to placebo.
Diabetes was a secondary outcome of the original trial. The diagnosis was self-reported, and most participants were older and white.
Long-term selenium supplementation appears to increase the risk for type 2 diabetes.
The value was derived from the log-rank test.
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