Jodi B. Segal, MD, MPH; Michael B. Streiff, MD; Eric B. Bass, MD, MPH
Potential Financial Conflicts of Interest: None disclosed.
Segal J., Streiff M., Bass E.; Weight-Based Low-Molecular-Weight Heparin versus Weight-Based Intravenous Unfractionated Heparin. Ann Intern Med. 2007;147:434. doi: 10.7326/0003-4819-147-6-200709180-00021
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Published: Ann Intern Med. 2007;147(6):434.
We appreciate the analyses by Dr. Umscheid and colleagues of a subgroup of the studies that were included in the systematic reviews we identified. These analyses confirm that there is little difference in outcomes (both efficacy and safety outcomes) between weight-based UFH and weight-based LMWH. We expect that practice patterns have changed since the publication of most of these trials; it is usual practice in most institutions to use a weight-based nomogram for intravenous heparin dosing. We are pleased that Dr. Umscheid and colleagues' analyses support the recommendations in the guidelines in this current era of weight-based dosing of both UFH and LMWH.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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