Heinke Kunst, MBBS, MD, MSC; Khalid S. Khan, MBBS, MSc, Mmed
Potential Financial Conflicts of Interest: None disclosed.
Kunst H., Khan K.; New Tests for the Diagnosis of Latent Tuberculosis Infection. Ann Intern Med. 2007;147:672-673. doi: 10.7326/0003-4819-147-9-200711060-00020
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Published: Ann Intern Med. 2007;147(9):672-673.
TO THE EDITOR:
We read Menzies and colleagues' meta-analysis of new tests for latent tuberculosis infection (1) with interest and generally concurred with the authors' inferences for research and practice. As the target condition in the review lacks a gold standard, we were dissatisfied with the use of sensitivity and specificity—measures of test accuracy that cannot be computed without verification of disease status—in data synthesis. It is important for researchers to establish the evidence base for incorporation of new tests in clinical practice concerning latent tuberculosis infection by using sound methods for evaluating tests without a gold standard (2), and we would like to highlight some key issues important for such research.
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