Anna N.A. Tosteson, ScD; Natasha K. Stout, PhD; Dennis G. Fryback, PhD; Suddhasatta Acharyya, PhD; Benjamin A. Herman, SM; Lucy G. Hannah, MS, MAT; Etta D. Pisano, MD; DMIST Investigators
Grant Support: By National Cancer Institute grants CA80098, CA79778, and CA88211.
Potential Financial Conflicts of Interest:Consultancies: D.G. Fryback (Dartmouth College). Grants received: D.G. Fryback (ACRIN). Institutional: D.G. Fryback (University of Wisconsin, which offers digital mammography services); E.D. Pisano (University of North Carolina, which receives research support from GE).
Reproducible Research Statement: DMIST contact personnel: http://www.acrin.org/PROTOCOLSUMMARYTABLE/PROTOCOL6652/6652ContactPersonnel/tabid/393/Default.aspx. Study protocol: Partial protocol (with information on how to obtain the full protocol) is available at http://www.acrin.org/Portals/0/Protocols/6652/A6652partial_summary.pdf. Statistical code and data set: Available with restriction in accordance with the ACRIN data-sharing policies at http://www.acrin.org/RESEARCHERS/POLICIES/DATAANDIMAGESHARINGPOLICY/DATAACCESSPOLICYDOCUMENT/tabid/475/Default.aspx.
Requests for Single Reprints: Anna N.A. Tosteson, ScD, Clinical Research HB7505, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756; e-mail, firstname.lastname@example.org.
Current Author Addresses: Dr. Tosteson: Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756.
Dr. Stout: Program in Health Decision Science, Department of Health Policy and Management, 718 Huntington Avenue, Harvard School of Public Health, Boston, MA 02115.
Dr. Fryback: Departments of Population Health Sciences and of Industrial and Systems Engineering, University of Wisconsin, 610 Walnut Street, Room 685, Madison, WI 53726.
Dr. Acharyya, Mr. Herman, and Ms. Hannah: Statistical Sciences Center, Brown University, Box G-121-7, 121 South Main Street, Providence, RI 02912.
Dr. Pisano: Department of Radiology and Biomedical Engineering of the Lineberger Comprehensive Cancer Center and Biomedical Research Imaging Center, CB700, 4th Floor, Bondurant Hall, Dean's Office, University of North Carolina School of Medicine, Chapel Hill, NC 27599.
Author Contributions: Conception and design: A.N.A. Tosteson, D.G. Fryback, E.D. Pisano.
Analysis and interpretation of the data: A.N.A. Tosteson, N.K. Stout, D.G. Fryback, S. Acharyya, B.A. Herman, L. Hannah, E.D. Pisano.
Drafting of the article: A.N.A. Tosteson, N.K. Stout, D.G. Fryback, S. Acharyya, B.A. Herman.
Critical revision of the article for important intellectual content: A.N.A. Tosteson, N.K. Stout, D.G. Fryback, S. Acharyya, B.A. Herman, E.D. Pisano.
Final approval of the article: A.N.A. Tosteson, N.K. Stout, D.G. Fryback, S. Acharyya, B.A. Herman, L. Hannah, E.D. Pisano.
Provision of study materials or patients: E.T. Pisano.
Statistical expertise: A.N.A. Tosteson, D.G. Fryback, S. Acharyya, B.A. Herman, L. Hannah.
Obtaining of funding: A.N.A. Tosteson, E.D. Pisano.
Administrative, technical, or logistic support: A.N.A. Tosteson, N.K. Stout, D.G. Fryback, B.A. Herman.
Collection and assembly of data: B.A. Herman, L. Hannah.
For a list of the DMIST clinical sites, principal investigators, and lead physicists, see the Appendix.
Tosteson AN, Stout NK, Fryback DG, Acharyya S, Herman BA, Hannah LG, et al. Cost-Effectiveness of Digital Mammography Breast Cancer Screening. Ann Intern Med. 2008;148:1-10. doi: 10.7326/0003-4819-148-1-200801010-00002
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Published: Ann Intern Med. 2008;148(1):1-10.
The American College of Radiology Imaging Network conducted the DMIST (Digital Mammography Imaging Screening Trial) (1), which enrolled 49 528 asymptomatic women presenting for screening mammography in the United States and Canada. In this study, the diagnostic accuracy of digital and film mammography did not statistically significantly differ across the sample. Nonetheless, the finding that digital mammography was more effective than conventional film mammography at detecting breast cancer in women younger than age 50 years, women who were pre- or perimenopausal, and women with dense breasts, with no increase in false-positive results, has increased the demand for digital mammography.
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Hematology/Oncology, High Value Care, Breast Cancer, Prevention/Screening.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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