Mark R. Goldstein, MD
Potential Financial Conflicts of Interest: None disclosed.
Goldstein MR. Analyzing the Results of the Treating to New Targets Study. Ann Intern Med. 2008;148:322. doi: 10.7326/0003-4819-148-4-200802190-00021
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Published: Ann Intern Med. 2008;148(4):322.
TO THE EDITOR:
In their secondary analysis of the TNT study, Wenger and colleagues (1) concluded that the findings support the use of intensive low-density lipoprotein cholesterol–lowering therapy in elderly individuals with established cardiovascular disease (1). Close scrutiny of the data contradicts their conclusion.
The secondary analysis of the TNT study compared the outcomes of 10 mg with 80 mg of atorvastatin daily in the 3809 patients 65 years of age or older for the 4.9-year study duration. The overall mortality rate over the study duration was 9.1% in participants randomly assigned to 80 mg of atorvastatin daily and 8.5% in participants randomly assigned to 10 mg of atorvastatin daily.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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