Vandana Menon, MD, PhD; Mark J. Sarnak, MD, MS; Michael G. Shlipak, MD, MPH
Potential Financial Conflicts of Interest: None disclosed.
Menon V, Sarnak MJ, Shlipak MG. Cystatin C, Renal Function, and Cardiovascular Risk. Ann Intern Med. 2008;148:324. doi: 10.7326/0003-4819-148-4-200802190-00024
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Published: Ann Intern Med. 2008;148(4):324.
Regarding our analyses examining cystatin C as a risk factor for outcomes in chronic kidney disease, we do not make the assertion that cystatin C is better than creatinine in diagnosing stage 3 kidney disease. Regarding the question about our methods, cystatin C was measured in frozen samples collected at baseline from participants of the randomized cohort of the Modification of Diet in Renal Disease Study, as stated in the Methods section. There is a precedent for using frozen stored samples to analyze cystatin C (1–3). Serum and plasma samples stored at temperatures ranging from room temperature to −20 °C and from 2 days to more than 1 month were found to be stable (4, 5). Our samples were stored at −70 °C.
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