Giuseppe Lippi, MD; Martina Montagnana, MD
Potential Financial Conflicts of Interest: None disclosed.
Lippi G, Montagnana M. d-Dimer Testing in Pregnancy: Clinically Useful, but at What Cost?. Ann Intern Med. 2008;148:484. doi: 10.7326/0003-4819-148-6-200803180-00020
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Published: Ann Intern Med. 2008;148(6):484.
TO THE EDITOR:
We read with interest the recent article by Chan and colleagues (1), which showed that the SimpliRED assay may be useful in pregnancy because a normal result would help rule out deep venous thrombosis (DVT) and would occur frequently enough to be clinically helpful. This is a very provocative conclusion, in that d-dimer testing is indispensable in the diagnostic approach to DVT (2), but its use has yet to be defined in pregnancy because of the questionable diagnostic efficiency (3). Therefore, we would like to express some considerations on the results of this clinical investigation.
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