Pragna Patel, MD, MPH; Debra L. Hanson, MS; Patrick S. Sullivan, DVM, PhD; Richard M. Novak, MD; Anne C. Moorman, BSN, MPH; Tony C. Tong, MS; Scott D. Holmberg, MD, MPH; John T. Brooks, MD; Adult and Adolescent Spectrum of Disease Project and HIV Outpatient Study Investigators
Patel P, Hanson DL, Sullivan PS, Novak RM, Moorman AC, Tong TC, et al. Incidence of Types of Cancer among HIV-Infected Persons Compared with the General Population in the United States, 1992–2003. Ann Intern Med. 2008;148:728-736. doi: 10.7326/0003-4819-148-10-200805200-00005
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Published: Ann Intern Med. 2008;148(10):728-736.
Antiretroviral therapy has improved survival of HIV-infected individuals and dramatically decreased cases of AIDS-defining cancer. However, some evidence from small or selected populations with AIDS suggests that non–AIDS-defining cancer cases have increased.
This study found that the incidence of several types of non–AIDS-defining cancer (Hodgkin lymphoma; melanoma; leukemia; and cancer of the liver, lung, anus, vagina, oropharynx, colon or rectum, and kidney) were significantly higher among a large, diverse, HIV-infected population than in the general population reported in the SEER database.
Patients infected with HIV—and their clinicians—should be alert for signs of non–AIDS-related cancer.
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Rates are unadjusted incidence rates per 100 000 person-years (PYs). Data for HIV-infected persons are drawn from the Adult and Adolescent Spectrum of Disease Project (ASD) and the HIV Outpatient Study (HOPS); general population data are estimated from Surveillance, Epidemiology, and End Results (SEER) program data, 1992–2003.
Data for HIV-infected persons are drawn from the Adult and Adolescent Spectrum of Disease Project (ASD) and the HIV Outpatient Study (HOPS); general population data are estimated from Surveillance, Epidemiology, and End Results (SEER) program data. P values of significant trends are depicted; dotted lines represent nonsignificant results. PY = person-year.
Data for HIV-infected persons are drawn from the Adult and Adolescent Spectrum of Disease Project (ASD) and the HIV Outpatient Study (HOPS); general population data are estimated from Surveillance, Epidemiology, and End Results (SEER) program data.
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Hematology/Oncology, HIV, Infectious Disease.
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