Pragna Patel, MD, MPH; Debra L. Hanson, MS; Patrick S. Sullivan, DVM, PhD; Richard M. Novak, MD; Anne C. Moorman, BSN, MPH; Tony C. Tong, MS; Scott D. Holmberg, MD, MPH; John T. Brooks, MD; Adult and Adolescent Spectrum of Disease Project and HIV Outpatient Study Investigators
Antiretroviral therapy has improved survival of HIV-infected individuals and dramatically decreased cases of AIDS-defining cancer. However, some evidence from small or selected populations with AIDS suggests that non–AIDS-defining cancer cases have increased.
This study found that the incidence of several types of non–AIDS-defining cancer (Hodgkin lymphoma; melanoma; leukemia; and cancer of the liver, lung, anus, vagina, oropharynx, colon or rectum, and kidney) were significantly higher among a large, diverse, HIV-infected population than in the general population reported in the SEER database.
Patients infected with HIV—and their clinicians—should be alert for signs of non–AIDS-related cancer.
Appendix Table 1.
Appendix Table 2.
Appendix Table 3.
Appendix Table 4.
Appendix Table 5.
Rates are unadjusted incidence rates per 100 000 person-years (PYs). Data for HIV-infected persons are drawn from the Adult and Adolescent Spectrum of Disease Project (ASD) and the HIV Outpatient Study (HOPS); general population data are estimated from Surveillance, Epidemiology, and End Results (SEER) program data, 1992–2003.
Data for HIV-infected persons are drawn from the Adult and Adolescent Spectrum of Disease Project (ASD) and the HIV Outpatient Study (HOPS); general population data are estimated from Surveillance, Epidemiology, and End Results (SEER) program data. P values of significant trends are depicted; dotted lines represent nonsignificant results. PY = person-year.
Data for HIV-infected persons are drawn from the Adult and Adolescent Spectrum of Disease Project (ASD) and the HIV Outpatient Study (HOPS); general population data are estimated from Surveillance, Epidemiology, and End Results (SEER) program data.
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Patel P, Hanson DL, Sullivan PS, Novak RM, Moorman AC, Tong TC, et al. Incidence of Types of Cancer among HIV-Infected Persons Compared with the General Population in the United States, 1992–2003. Ann Intern Med. 2008;148:728-736. doi: 10.7326/0003-4819-148-10-200805200-00005
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Published: Ann Intern Med. 2008;148(10):728-736.
Hematology/Oncology, HIV, Infectious Disease.
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