Aine M. Kelly, MD, MS; Ben Dwamena, MD; Ruth C. Carlos, MD, MS
Potential Financial Conflicts of Interest: None disclosed.
Kelly A., Dwamena B., Carlos R.; Is There Enough Evidence to Support Use of N-Acetylcysteine in Contrast-Induced Nephropathy?. Ann Intern Med. 2008;149:215-216. doi: 10.7326/0003-4819-149-3-200808050-00019
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Published: Ann Intern Med. 2008;149(3):215-216.
We thank Dr. Trivedi for detecting 2 errors in our article. First, we included 26 studies of N-acetylcysteine, not 30 as indicated in Figure 1. Second, we erroneously cited a review related to the selection of contrast media (1)—we intended to cite a 1994 study by Solomon and colleagues (2). In addition, we agree with Dr. Trivedi that substantial heterogeneity of studies evaluating N-acetylcysteine makes the conclusions of our analysis far from definitive. As stated in our article, head-to-head trials of available agents are needed to define the most effective and safe strategy of preventing contrast-induced nephropathy. Finally, the editors have published a correction about the Editors' Notes accompanying our article (3).
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