Bryan Kestenbaum, MD, MS
Potential Financial Conflicts of Interest: None disclosed.
Kestenbaum B.; Why Choose Serum Cystatin C Levels over Serum Creatinine Levels as a Serologic Marker of Kidney Function?. Ann Intern Med. 2008;149:284. doi: 10.7326/0003-4819-149-4-200808190-00017
Download citation file:
Published: Ann Intern Med. 2008;149(4):284.
We chose serum cystatin C level as a serologic marker of kidney function for 3 reasons. First, serum cystatin C levels provide a more precise estimate of the GFR than do serum creatinine levels. In a recent pooled analysis, cystatin C levels accounted for 82% of the variation in radionucleotide-measured GFR, whereas serum creatinine levels accounted for 74% (1). Second, cystatin C levels are more accurate than serum creatinine levels for detecting early disturbances in kidney function (2, 3). Third, the Modification of Diet in Renal Disease equation incorporates terms for age, race, and sex, potentially confusing associations with incident hypertension. In our adjusted models, neither serum creatinine level nor estimated GFR by the Modification of Diet in Renal Disease equation was statistically significantly associated with incident hypertension.
to gain full access to the content and tools.
Learn more about subscription options.
Register Now for a free account.
Copyright © 2016 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only