Justin W. Timbie, PhD
Potential Financial Conflicts of Interest: None disclosed.
Timbie J.; Monitoring Cholesterol Levels: Understanding Variance and Finding the Most Useful Data. Ann Intern Med. 2008;149:436. doi: 10.7326/0003-4819-149-6-200809160-00017
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Published: Ann Intern Med. 2008;149(6):436.
TO THE EDITOR:
I read with great interest the article by Glasziou and colleagues (1), which provided useful variance parameters for a simulation study I am currently conducting. I believe the authors made 2 errors, however, and although neither error alters the conclusions of their study, researchers using the reported estimates for other work might come to erroneous conclusions depending on which estimates they use.
First, the variance estimates reported on page 659 (column 2, paragraphs 3 and 4) are in the wrong units. The units should be mmol2/L2 (mg2/dL2) and not mmol/L (mg/dL).
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