Nicola Mumoli, MD; Marco Cei, MD
Potential Financial Conflicts of Interest: None disclosed.
Mumoli N, Cei M. Clomipramine-Induced Diabetes. Ann Intern Med. 2008;149:595-596. doi: 10.7326/0003-4819-149-8-200810210-00021
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Published: Ann Intern Med. 2008;149(8):595-596.
Background: Clomipramine is a tricyclic agent with both antidepressant and antiobsessional properties. Like other tricyclics, clomipramine inhibits uptake of norepinephrine, dopamine, and serotonin. Clomipramine has anticholinergic side effects: retention of urine, reduced intestinal motility, increased eye pressure, orthostatic hypotension, and heart rhythm disturbance. Other side effects reported include weight gain, vomiting, diarrhea, and sedation.
Objective: To describe an 84-year-old woman who developed diabetes during treatment with clomipramine for depression.
Case Report: The patient was admitted to our hospital in December 2006 because of polyuria, dehydration, and obtunded sensorium 5 months after starting treatment with clomipramine, 25 mg/d, to control depression episodes. Her medical history was notable for well-controlled hypertension and atrial fibrillation; her medications were aspirin and irbesartan.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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