Ann G. Zauber, PhD; Iris Lansdorp-Vogelaar, MS; Amy B. Knudsen, PhD; Janneke Wilschut, MS; Marjolein van Ballegooijen, MD, PhD; Karen M. Kuntz, ScD
Zauber AG, Lansdorp-Vogelaar I, Knudsen AB, Wilschut J, van Ballegooijen M, Kuntz KM. Evaluating Test Strategies for Colorectal Cancer Screening: A Decision Analysis for the U.S. Preventive Services Task Force. Ann Intern Med. 2008;149:659-669. doi: 10.7326/0003-4819-149-9-200811040-00244
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Published: Ann Intern Med. 2008;149(9):659-669.
The U.S. Preventive Services Task Force requested a decision analysis to inform their update of recommendations for colorectal cancer screening.
To assess life-years gained and colonoscopy requirements for colorectal cancer screening strategies and identify a set of recommendable screening strategies.
Decision analysis using 2 colorectal cancer microsimulation models from the Cancer Intervention and Surveillance Modeling Network.
Derived from the literature.
U.S. average-risk 40-year-old population.
Fecal occult blood tests (FOBTs), flexible sigmoidoscopy, or colonoscopy screening beginning at age 40, 50, or 60 years and stopping at age 75 or 85 years, with screening intervals of 1, 2, or 3 years for FOBT and 5, 10, or 20 years for sigmoidoscopy and colonoscopy.
Number of life-years gained compared with no screening and number of colonoscopies and noncolonoscopy tests required.
Beginning screening at age 50 years was consistently better than at age 60. Decreasing the stop age from 85 to 75 years decreased life-years gained by 1% to 4%, whereas colonoscopy use decreased by 4% to 15%. Assuming equally high adherence, 4 strategies provided similar life-years gained: colonoscopy every 10 years, annual Hemoccult SENSA (Beckman Coulter, Fullerton, California) testing or fecal immunochemical testing, and sigmoidoscopy every 5 years with midinterval Hemoccult SENSA testing. Annual Hemoccult II and flexible sigmoidoscopy every 5 years alone were less effective.
The results were most sensitive to beginning screening at age 40 years.
The stop age for screening was based only on chronologic age.
The findings support colorectal cancer screening with the following: colonoscopy every 10 years, annual screening with a sensitive FOBT, or flexible sigmoidoscopy every 5 years with a midinterval sensitive FOBT from age 50 to 75 years.
The opportunity to intervene in the natural history through screening is noted.
The numbers represent the following: age to beginage to stop screening, interval. MISCAN= Microsimulation Screening Analysis; SimCRC= Simulation Model of Colorectal Cancer.
SENSA= Hemoccult SENSA; FIT= fecal immunochemical testing; FSIG= flexible sigmoidoscopy; MISCAN= Microsimulation Analysis Model; SimCRC= Simulation Model of Colorectal Cancer. *The numbers represent the following: age to beginage to stop screening, interval.
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