Mustafa Bakir, MD; Kerry A. Millington, DPhil; Ahmet Soysal, MD; Jonathan J. Deeks, PhD; Serpil Efee; Yasemin Aslan, SRN; Davinder P.S. Dosanjh, DPhil; Ajit Lalvani, DM
Note: Drs. Bakir and Millington contributed equally to this work.
Acknowledgment: The authors thank the children who took part in the study and their parents. They also acknowledge the crucial support of the Istanbul Association for the Fight Against Tuberculosis and the physicians and nurses of the 7 government-run tuberculosis clinics in the Anatolian side of Istanbul.
Grant Support: By the Wellcome Trust and the United Nations (International) Children's Fund/United Nations Development Programme/World Bank/World Health Organization Special Programme for Research and Training in Tropical Diseases, a UK Department of Health Senior Fellowship in Evidence Synthesis (Dr. Deeks), and the Sir Halley Stewart Trust (Dr. Dosanjh's PhD studentship). Dr. Lalvani is a Wellcome Senior Research Fellow in Clinical Science, and Dr. Millington was a Wellcome Trust Prize PhD student. Both are members of the Wellcome Trust-funded Centre for Respiratory Infection, Imperial College London.
Potential Financial Conflicts of Interest:Consultancies: A. Lalvani (Oxford Immunotec Ltd. [nonexecutive director from 2003 to 2007]). Stock ownership or options (other than mutual funds): A. Lalvani (Oxford Immunotec Ltd.), University of Oxford (Oxford Immunotec Ltd.). Patents received: A. Lalvani (T-cell–based diagnosis of tuberculosis infection.) Patents pending: K.A. Millington (T-cell–based diagnosis of tuberculosis infection.), D.P.S. Dosanjh (T-cell–based diagnosis of tuberculosis infection.), A. Lalvani (T-cell–based diagnosis of tuberculosis infection.)
Reproducible Research Statement:Study protocol: Not available. Statistical code and data set: Available to academic investigators from Dr. Lalvani (e-mail, email@example.com) after agreement is made by written request.
Requests for Single Reprints: Ajit Lalvani, DM, Tuberculosis Immunology Group, Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College London, Norfolk Place, London W2 1PG, United Kingdom; e-mail, firstname.lastname@example.org.
Current Author Addresses: Drs. Bakir and Soysal, Ms. Efee, and Ms. Aslan: Department of Paediatrics, Marmara University School of Medicine, Tophanelioglu Caad. No. 13-15, Altunizade, Istanbul, Turkey.
Drs. Millington, Dosanjh, and Lalvani: Tuberculosis Immunology Group, Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College London, Norfolk Place, London W2 1PG, United Kingdom.
Dr. Deeks: Unit of Public Health, Epidemiology and Biostatistics, School of Population Health and Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.
Author Contributions: Conception and design: M. Bakir, A. Lalvani.
Analysis and interpretation of the data: M. Bakir, K.A. Millington, A. Soysal, J.J. Deeks, D.P.S. Dosanjh, A. Lalvani.
Drafting of the article: K.A. Millington, A. Lalvani.
Critical revision of the article for important intellectual content: K.A. Millington, J.J. Deeks, A. Lalvani.
Final approval of the article: M. Bakir, K.A. Millington, A. Soysal, J.J. Deeks, S. Efee, Y. Aslan, D.P.S. Dosanjh, A. Lalvani.
Provision of study materials or patients: M. Bakir, A. Soysal, S. Efee, Y. Aslan.
Statistical expertise: K.A. Millington, J.J. Deeks, A. Lalvani.
Obtaining of funding: M. Bakir, A. Lalvani.
Administrative, technical, or logistic support: M. Bakir, A. Soysal, S. Efee, Y. Aslan, A. Lalvani.
Collection and assembly of data: M. Bakir, K.A. Millington, A. Soysal, S. Efee, Y. Aslan, D.P.S. Dosanjh, A. Lalvani.
Bakir M, Millington KA, Soysal A, Deeks JJ, Efee S, Aslan Y, et al. Prognostic Value of a T-Cell–Based, Interferon-γ Biomarker in Children with Tuberculosis Contact. Ann Intern Med. 2008;149:777-786. doi: 10.7326/0003-4819-149-11-200812020-00248
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Published: Ann Intern Med. 2008;149(11):777-786.
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