Daniel Bogdanov Petrov, MD
Petrov D.; Starvation Diets as a Cause of Acquired Long QT Syndrome. Ann Intern Med. 2009;150:501. doi: 10.7326/0003-4819-150-7-200904070-00014
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Published: Ann Intern Med. 2009;150(7):501.
Background: Prolongation of the rate-corrected QT interval (QTc) and ventricular arrhythmias have been described in persons on starvation diets (1). Prolongation of the QTc interval as measured by standard 12-lead electrocardiography is an independent risk factor for sudden death due to cardiac arrest (2).
Objective: To determinate whether long-term weight loss over 7 weeks can influence cardiac repolarization as indicated by the electrocardiographic QT interval.
Methods: The electrocardiographic QT, RR, and QTc (QT/RR(0,5)) intervals were assessed in 29 healthy obese (body mass index >27 kg/m2) persons on a very-low-calorie diet (800 kcal/d) for 7 weeks. The intervals, serum albumin, and electrolytes were measured at baseline, once weekly, and at the end of diet therapy. Twelve-lead electrocardiograms were obtained from all patients in a supine position after 10 minutes at rest. The electrocardiograms were recorded at standard gain (10 mv/mm) and speed (25 mm/s). The QT interval was measured from the onset of the QRS complex to the end of the T wave in all leads in which the end of the T wave could be clearly defined. The QT intervals were corrected for heart rate by using the Bazett formula. Patients with atrial fibrillation, bundle-branch block, and pacemakers were excluded. All patients gave informed consent.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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