Jack A. Yanovski, MD, PhD; Shamik J. Parikh, MD; Lisa B. Yanoff, MD; Blakeley I. Denkinger, MPH, RD; Karim A. Calis, PharmD, MPH; James C. Reynolds, MD; Nancy G. Sebring, MEd, RD; Teresa McHugh, RN
Yanovski JA, Parikh SJ, Yanoff LB, Denkinger BI, Calis KA, Reynolds JC, et al. Effects of Calcium Supplementation on Body Weight and Adiposity in Overweight and Obese Adults: A Randomized Trial. Ann Intern Med. 2009;150:821-829. doi: 10.7326/0003-4819-150-12-200906160-00005
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Published: Ann Intern Med. 2009;150(12):821-829.
Some data suggest that increasing calcium intake may help prevent weight gain.
To test the hypothesis that calcium supplementation can prevent weight gain in persons who are overweight or obese.
Randomized, placebo-controlled trial. Randomization was computer-generated, and allocation was assigned by pharmacy personnel who prepared intervention and placebo capsules. Participants, providers, and those who assessed outcomes were blinded to study group assignment.
Single research center.
340 overweight (body mass index [BMI], 25 to <30 kg/m2) and obese (BMI â‰¥30 kg/m2) adults (mean age, 38.8 years [SD, 10.5]).
Calcium carbonate (elemental calcium, 1500 mg/d) (nÂ = 170) or placebo (nÂ = 170) with meals for 2 years.
Changes in body weight and fat mass (primary outcomes).
Seventy-five percent of participants completed the trial (78% received calcium; 73% received placebo). There were no statistically or clinically significant differences between the calcium and placebo groups in change in body weight (difference, 0.02 kg [95% CI, âˆ’1.64 to 1.69 kg]; PÂ = 0.98), BMI (difference, 0.32 kg/m2 [CI, âˆ’0.41 to 1.02 kg/m2]; PÂ = 0.39), or body fat mass (difference, 0.39 kg [CI, âˆ’1.04 to 1.92 kg]; PÂ = 0.55). Parathyroid hormone concentrations decreased in the calcium group compared with the placebo group (difference, âˆ’0.71 pmol/L [CI, âˆ’1.28 to âˆ’0.13 pmol/L]).
The study took place at a research center, and its sample was mostly women.
Dietary supplementation with elemental calcium, 1500 mg/d, for 2 years had no statistically or clinically significant effects on weight in overweight and obese adults. Calcium supplementation is unlikely to have clinically significant efficacy as a preventive measure against weight gain in such patients.
Office of Dietary Supplements and Intramural Research Program of the National Institutes of Health.
Some data suggest that body weight is inversely associated with calcium intake, increasing the possibility that supplemental calcium might facilitate weight loss or prevent weight gain.
Researchers randomly assigned overweight and obese patients to supplemental calcium or placebo and found no between-group differences in measures of weight change.
Trial participants were almost all women.
Calcium supplementation is unlikely to prevent weight gain in persons who are overweight or obese.
BMI = body mass index.
Measured means (95% CIs) for weight (top), BMI (middle), and fat mass (bottom) in participants randomly assigned to calcium or placebo are shown. There were no significant differences between groups at any time point. BMI = body mass index.
Appendix Table 1.
Appendix Table 2.
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