Tisha R. Joy, MD; Robert A. Hegele, MD
Joy TR, Hegele RA. Narrative Review: Statin-Related Myopathy. Ann Intern Med. 2009;150:858-868. doi: 10.7326/0003-4819-150-12-200906160-00009
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Published: Ann Intern Med. 2009;150(12):858-868.
Statin-related myopathy is a clinically important cause of statin intolerance and discontinuation. The spectrum of statin-related myopathy ranges from common but clinically benign myalgia to rare but life-threatening rhabdomyolysis. Observational studies suggest that myalgia can occur in up to 10% of persons prescribed statins, whereas rhabdomyolysis continues to be rare. The mechanisms of statin-related myopathy are unclear. Options for managing statin myopathy include statin switching, particularly to fluvastatin or low-dose rosuvastatin; nondaily dosing regimens; nonstatin alternatives, such as ezetimibe and bile acidâ€“binding resins; and coenzyme Q10 supplementation. Few of these strategies have high-quality evidence supporting them. Because statin-related myopathy will probably become more common with greater numbers of persons starting high-dose statin therapy and the increasing stringency of low-density lipoprotein cholesterol level targets, research to better identify patients at risk for statin myopathy and to evaluate management strategies for statin-related myopathy is warranted.
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Cardiology, Dyslipidemia, Coronary Risk Factors.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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