Reimar W. Thomsen, MD, PhD; W. Marieke Schoonen, MSc, PhD; Dóra K. Farkas, MSc; Anders Riis, MSc; Jacob Jacobsen, MSc; Jon P. Fryzek, PhD; Henrik Toft Sørensen, MD, DMSc
Grant Support: By Amgen, the Clinical Epidemiological Research Foundation at Aarhus University, and the Karen Elise Jensens Foundation.
Potential Conflicts of Interest:Employment: W.M. Schoonen (Amgen), J.P. Fryzek (Amgen). Stock ownership or options (other than mutual funds): W.M. Schoonen (Amgen), J.P. Fryzek (Amgen).
Reproducible Research Statement:Study protocol and statistical code: Available from Dr. Sørensen (e-mail, firstname.lastname@example.org). Data set: The Danish Data Protection Agency does not allow transferral of the project data to external research institutions. Most of the source data are stored with Statistics Denmark and can be made available for analysis from www.dst.dk/research.
Requests for Single Reprints: Reimar W. Thomsen, MD, PhD, Department of Clinical Epidemiology, Aarhus University Hospital, Aalborg Hospital Science and Innovation Center, Søndre Skovvej 15, DK-9000 Aalborg, Denmark; e-mail, email@example.com.
Current Author Addresses: Dr. Thomsen: Department of Clinical Epidemiology, Aarhus University Hospital, Aalborg Hospital Science and Innovation Centre, Søndre Skovvej 15, DK-9000 Aalborg, Denmark.
Dr. Schoonen: Amgen, 1 Uxbridge Business Park, Sanderson Road, Uxbridge, Middlesex UB8 1DH, United Kingdom.
Ms. Farkas, Mr. Riis, Mr. Jacobsen, and Dr. Sørensen: Department of Clinical Epidemiology, Aarhus University Hospital, Olof Palmes Alle 43-45, DK-8200 Århus Nord, Denmark.
Dr. Fryzek: Amgen, One Amgen Center Drive, Thousand Oaks, CA 91360.
Author Contributions: Conception and design: D.K. Farkas, J. Jacobsen, R.W. Thomsen, W.M. Schoonen, A. Riis, J.P. Fryzek, H.T. Sørensen.
Analysis and interpretation of the data: R.W. Thomsen, W.M. Schoonen, D.K. Farkas, A. Riis, J. Jacobsen, J.P. Fryzek, H.T. Sørensen.
Drafting of the article: R.W. Thomsen, W.M. Schoonen, J.P. Fryzek.
Critical revision of the article for important intellectual content: D.K. Farkas, J. Jacobsen, R.W. Thomsen, W.M. Schoonen, J.P. Fryzek, H.T. Sørensen.
Final approval of the article: R.W. Thomsen, W.M. Schoonen, D.K. Farkas, A. Riis, J. Jacobsen, J.P. Fryzek, H.T. Sørensen.
Administrative, technical, or logistic support: D.K. Farkas, J. Jacobsen.
Statistical expertise: W.M. Schoonen, D.K. Farkas, A. Riis, J. Jacobsen, J.P. Fryzek.
Collection and assembly of data: A. Riis.
Thomsen RW, Schoonen WM, Farkas DK, Riis A, Jacobsen J, Fryzek JP, et al. Risk for Hospital Contact With Infection in Patients With Splenectomy: A Population-Based Cohort Study. Ann Intern Med. 2009;151:546-555. doi: 10.7326/0003-4819-151-8-200910200-00008
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Published: Ann Intern Med. 2009;151(8):546-555.
The spleen hosts important immune cells that are essential to the elimination of bloodborne pathogens, particularly encapsulated bacteria (1, 2). Medically indicated splenectomy is associated with pneumonia, bacteremia, severe sepsis, and other severe infections (3–9). The magnitude and duration of increased infection risk, however, is debated (10). Few studies have followed splenectomized patients for more than 1 year (3, 5, 6, 8, 9), and confounding by splenectomy indications and other comorbid conditions could have affected the findings. In addition, the longer-term risk for infection in splenectomized patients has not been quantified. Such data are important for evaluating splenectomy-associated risks and for better understanding patients' clinical course (10). We conducted a population-based assessment in Denmark of the risk for hospital contacts involving infection among splenectomized patients compared with the general population and with similar groups of unsplenectomized patients. We also examined variations in the risk for infections by splenectomy indication and by time since surgical procedure.
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Hospital Medicine, Infectious Disease.
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