Georg M. Schuetz, MS; Niki Maria Zacharopoulou, MD; Peter Schlattmann, MD, PhD; Marc Dewey, MD, PhD
Acknowledgment: The authors thank all contacted authors who provided extra data for this meta-analysis.
Potential Conflicts of Interest: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M09-1663.
Requests for Single Reprints: Marc Dewey, MD, PhD, Department of Radiology, Charité Medical School, Humboldt-Universität zu Berlin, Freie Universität Berlin, Charitéplatz 1, 10117 Berlin, Germany; e-mail, firstname.lastname@example.org.
Current Author Addresses: Mr. Schuetz and Drs. Zacharopoulou and Dewey: Department of Radiology, Charité Medical School, Humboldt-Universität zu Berlin, Freie Universität Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Dr. Schlattmann: Department of Biostatistics and Clinical Epidemiology, Charité Medical School, Humboldt-Universität zu Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Author Contributions: Conception and design: G.M. Schuetz, M. Dewey.
Analysis and interpretation of the data: G.M. Schuetz, N.M. Zacharopoulou, P. Schlattmann, M. Dewey.
Drafting of the article: G.M. Schuetz, P. Schlattmann, M. Dewey.
Critical revision of the article for important intellectual content: N.M. Zacharopoulou.
Final approval of the article: G.M. Schuetz, N.M. Zacharopoulou, P. Schlattmann, M. Dewey.
Statistical expertise: P. Schlattmann.
Administrative, technical, or logistic support: M. Dewey.
Collection and assembly of data: G.M. Schuetz, N.M. Zacharopoulou.
Schuetz GM, Zacharopoulou NM, Schlattmann P, Dewey M. Meta-analysis: Noninvasive Coronary Angiography Using Computed Tomography Versus Magnetic Resonance Imaging. Ann Intern Med. 2010;152:167-177. doi: 10.7326/0003-4819-152-3-201002020-00008
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Published: Ann Intern Med. 2010;152(3):167-177.
Two imaging techniques, multislice computed tomography (CT) and magnetic resonance imaging (MRI), have evolved for noninvasive coronary angiography.
To compare CT and MRI for ruling out clinically significant coronary artery disease (CAD) in adults with suspected or known CAD.
MEDLINE, EMBASE, and ISI Web of Science searches from inception through 2 June 2009 and bibliographies of reviews.
Prospective English- or German-language studies that compared CT or MRI with conventional coronary angiography in all patients and included sufficient data for compilation of 2 Ã— 2 tables.
2 investigators independently extracted patient and study characteristics; differences were resolved by consensus.
89 and 20 studies (comprising 7516 and 989 patients) assessed CT and MRI, respectively. Bivariate analysis of data yielded a mean sensitivity and specificity of 97.2% (95% CI, 96.2% to 98.0%) and 87.4% (CI, 84.5% to 89.8%) for CT and 87.1% (CI, 83.0% to 90.3%) and 70.3% (CI, 58.8% to 79.7%) for MRI. In studies that included only patients with suspected CAD, sensitivity and specificity of CT were 97.6% (CI, 96.1% to 98.5%) and 89.2% (CI, 86.0% to 91.8%). Covariate analysis yielded a significantly higher sensitivity for CT scanners with more than 16 rows (98.1% [CI, 97.0% to 99.0%]; PÂ < 0.050) than for older-generation scanners (95.6% [CI, 94.0% to 97.0%]). Heart rates less than 60 beats/min during CT yielded significantly better values for sensitivity than did higher heart rates (PÂ < 0.001).
Few studies investigated coronary angiography with MRI. Only 5 studies were direct head-to-head comparisons of CT and MRI. Covariate analyses explained only part of the observed heterogeneity.
For ruling out CAD, CT is more accurate than MRI. Scanners with more than 16 rows improve sensitivity, as do slowed heart rates.
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