Nancy R. Cook, ScD
Potential Conflicts of Interest: None disclosed.
Cook NR. The Case for C-Reactive Protein as a Risk Marker for Coronary Heart Disease. Ann Intern Med. 2010;152:406. doi: 10.7326/0003-4819-152-6-201003160-00020
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Published: Ann Intern Med. 2010;152(6):406.
TO THE EDITOR:
Buckley and colleagues (1) state that the utility of measuring C-reactive protein (CRP) is uncertain and conclude that routine screening by CRP levels cannot be recommended. The reasoning behind this conclusion, however, seems flawed. First, since the literature review in 2007, additional articles have been published, particularly ones featuring risk reclassification (including the Reynolds Risk Score for men  and the analysis of high-sensitivity CRP in the Framingham cohort ). The latter work should replace the cited negative study from Framingham, which did not use the high-sensitivity assay.
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