William S. Yancy, MD, MHS; Matthew L. Maciejewski, PhD; Kevin A. Schulman, MD
Disclaimer: This material is the result of work supported with resources and the use of facilities at the Veterans Affairs Medical Center in Durham, North Carolina. The views expressed in this article are those of the authors and do not necessarily reflect the position or policy of the Department of Veterans Affairs or the U.S. government.
Grant Support: Dr. Yancy has received research grants from the Robert C. Atkins Foundation.
Potential Conflicts of Interest: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M10-1774.
Requests for Single Reprints: William S. Yancy Jr., MD, MHS, Veterans Affairs Medical Center (152), 508 Fulton Street, Durham, NC 27705; e-mail, firstname.lastname@example.org.
Current Author Addresses: Drs. Yancy and Maciejewski: Veterans Affairs Medical Center, Mailstop 152, 508 Fulton Street, Durham, NC 27705.
Dr. Schulman: Center for Clinical and Genetic Economics, Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715.
Yancy WS, Maciejewski ML, Schulman KA. Animal, Vegetable, or … Clinical Trial?. Ann Intern Med. 2010;153:337-339. doi: 10.7326/0003-4819-153-5-201009070-00009
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Published: Ann Intern Med. 2010;153(5):337-339.
Several clinical trials in the past 10 years have demonstrated that a low-carbohydrate, high-fat, high-protein diet is at least as effective as a calorie-restricted, high-carbohydrate, low-fat diet for weight loss and improvement of risk factors (blood pressure, serum lipid levels, and glycemia) (1–3). These clinical trial results conflict with older observational studies that linked dietary fat with poor health outcomes. Newer observational studies and systematic reviews, however, have absolved fat (with the exception of trans fat) as a detriment to health, and some have implicated refined sugars and starches instead (4–8).
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Cardiology, Dyslipidemia, Coronary Risk Factors.
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