The CLOTS (Clots in Legs Or sTockings after Stroke) Trial Collaboration
Acknowledgment: The authors thank all the patients and their families who participated in the CLOTS trials, the nursing and radiology staff who assisted at collaborating sites, and the United Kingdom stroke research network staff, without whom the trial would not have been possible.
Grant Support: By the Chief Scientist Office of the Scottish Government (reference CZH/4/7), Chest Heart and Stroke Scotland (reference 03/01), and the Medical Research Council of the UK (reference G0200531). Dr. Marcello Naccarato, a neurologist at the Azienda Ospedaliera “Ospedali Riuniti,” Trieste, Italy, performed the literature searches for trials of graduated compression stockings and prepared the resulting Cochrane Collaboration systematic review. Tyco Healthcare (Covidien) donated supplies of stockings and provided training in their use to participating centers.
Potential Conflicts of Interest: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M10-1009.
Reproducible Research Statement:Study protocol: Available at www.clotstrial.com. Statistical code: Available from Dr. Dennis (e-mail, firstname.lastname@example.org). Data set: Will be available via the open-access Edinburgh Data Repository after publication of the main papers.
Requests for Single Reprints: Martin Dennis, MD, Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, United Kingdom; e-mail, email@example.com.
Current Author Addresses: Drs. Dennis and Sandercock: Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, United Kingdom.
Dr. Reid: Borders General Hospital, Melrose TD6 9BS, United Kingdom.
Ms. Graham: Epidemiology and Statistics Core, Wellcome Trust Clinical Research Facility, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, United Kingdom.
Dr. Murray: Centre for Population Health Sciences, The University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, United Kingdom.
Dr. Venables: The Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, United Kingdom.
Dr. Rudd: St. Thomas' Hospital, Lambeth Palace Road, 9th Floor, North Wing, London SE1 7EH, United Kingdom.
Ms. Bowler: General Services, Pentland House, 47 Robb's Loan, Edinburgh EH14 1TY, United Kingdom.
Author Contributions: Conception and design: M. Dennis, P. Sandercock, A. Rudd.
Analysis and interpretation of the data: M. Dennis, P. Sandercock, J. Reid, C. Graham, G. Murray.
Drafting of the article: M. Dennis, P. Sandercock, C. Graham.
Critical revision of the article for important intellectual content: M. Dennis, P. Sandercock, G. Murray, G. Venables.
Final approval of the article: M. Dennis, P. Sandercock, J. Reid, C. Graham, G. Murray, G. Venables, A. Rudd, G. Bowler.
Provision of study materials or patients: M. Dennis, J. Reid.
Statistical expertise: C. Graham, G. Murray.
Obtaining of funding: M. Dennis, P. Sandercock.
Administrative, technical, or logistic support: M. Dennis, P. Sandercock, G. Bowler.
Collection and assembly of data: M. Dennis.
For a list of the CLOTS Trial collaborators, see the Appendix.
The CLOTS (Clots in Legs Or sTockings after Stroke) Trial Collaboration. Thigh-Length Versus Below-Knee Stockings for Deep Venous Thrombosis Prophylaxis After Stroke: A Randomized Trial. Ann Intern Med. 2010;153:553-562. doi: 10.7326/0003-4819-153-9-201011020-00280
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Published: Ann Intern Med. 2010;153(9):553-562.
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