Michael R. Littner, MD
Littner M.; Chronic Obstructive Pulmonary Disease. Ann Intern Med. 2011;154:ITC4-1. doi: 10.7326/0003-4819-154-7-201104050-01004
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Published: Ann Intern Med. 2011;154(7):ITC4-1.
Chronic obstructive pulmonary disease (COPD) is a treatable, preventable, and partially reversible disease characterized by progressive airflow obstruction documented by spirometry; it is associated with an abnormal inflammatory response of the lungs to noxious particles or gases (1–4).
Between 10% and 20% of COPD in the United States is estimated to be caused by occupational or other exposure to chemical vapors, irritants, and fumes. However, a recent review suggested that the percentage of patients with COPD who never smoked is 25% in the United States and may vary worldwide between about 15% (Japan) and 48% (South Africa), with higher rates in women (5). More information is needed to determine the role of inhaled irritants other than cigarette smoke, such as those found in outdoor air pollution, and with indoor products of biomass fuels, such as wood-burning stoves.
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Pulmonary/Critical Care, Chronic Obstructive Airway Disease, Prevention/Screening.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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