Carl Power, PhD; John E.J. Rasko, MBBS, PhD
Potential Conflicts of Interest: None disclosed. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M10-1697.
Requests for Single Reprints: John E.J. Rasko, MBBS, PhD, Centenary Institute, Locked Bag 6, Newtown NSW 2042, Australia; e-mail, email@example.com.
Current Author Addresses: Drs. Power and Rasko: Centenary Institute, Locked Bag 6, Newtown NSW 2042, Australia.
Author Contributions: Conception and design: C. Power, J.E.J. Rasko
Drafting of the article: C. Power, J.E.J. Rasko.
Critical revision of the article for important intellectual content: C. Power, J.E.J. Rasko.
Final approval of the article: C. Power, J.E.J. Rasko.
Power C., Rasko J.; Will Cell Reprogramming Resolve the Embryonic Stem Cell Controversy? A Narrative Review. Ann Intern Med. 2011;155:114-121. doi: 10.7326/0003-4819-155-2-201107190-00007
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Published: Ann Intern Med. 2011;155(2):114-121.
In the past few years, relatively straightforward laboratory techniques have been developed to reprogram normal body cells to enter an embryonic stem cell–like state. Not only do these induced pluripotent stem cells hold great medical promise—perhaps greater than that of embryonic stem cells—but they also have escaped the ethical controversy in which the latter is mired.
This article examines how cell reprogramming is likely to transform regenerative and reproductive medicine and highlights some of the medical, moral, and political hurdles that it faces. It also argues that induced pluripotent stem cells are more ethically problematic than most people believe and that cell reprogramming will not solve the stem cell controversy but complicate it further.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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