T. Jake Liang, MD; Barbara Rehermann, MD; Leonard B. Seeff, MD; Jay H. Hoofnagle, MD
The location of HCV genes, proposed functions of gene products, and the 5′ and 3′ untranslated regions ( and ) are shown. Numbering refers to nucleotide positions of genes.
Although the hepatocyte is depicted as the target cell of hepatitis C virus ( )-specific immune response here, other cells, including dendritic cells and macrophages, are also important in antigen presentation to the immune system. CTL = cytotoxic T cell; IL = interleukin; MHC = major histocompatibility complex; TCR = T-cell receptor; Th = T helper; Th1 = helper T cells with a type 1 cytokine profile; Th2 = helper T cells with a type 2 cytokine profile; TNF = tumor necrosis factor.
Survival of 100% is shown as 1 on the y axis.
The total height of the bars represents the end-of-treatment response rate; the white portion represents the sustained response rate. Data are shown for 1744 patients (the number in each treatment group is given in parentheses) from two large prospective clinical trials . Numbers at the top of the bars represent exact percentages.
The white bars represent patients with genotype 1 and the few patients with genotypes 4, 5, and 6; the striped bars represent patients with genotypes 2 and 3. Data are shown for 1744 patients (the number in each treatment group is given in parentheses) from two large prospective clinical trials . Numbers at the top of the bars represent exact percentages.
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T. Jake Liang, Barbara Rehermann, Leonard B. Seeff, Jay H. Hoofnagle. Pathogenesis, Natural History, Treatment, and Prevention of Hepatitis C. Ann Intern Med. 2000;132:296–305. doi: 10.7326/0003-4819-132-4-200002150-00008
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Published: Ann Intern Med. 2000;132(4):296-305.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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