Matthew J. Crowley, MD; Douglas C. McCrory, MD, MHS; Ranee Chatterjee, MD, MPH; Jennifer M. Gierisch, PhD; Evan R. Myers, MD, MPH; Kristine M. Schmit, MD, MPH; Remy R. Coeytaux, MD, PhD; Christoph U. Correll, MD; Amy S. Kendrick, RN, MSN; Gillian D. Sanders, PhD
Disclaimer: The authors of this article are responsible for its content. Statements in this article should not be construed as endorsement by the U.S. Department of Veterans Affairs.
Acknowledgment: The authors thank Megan M. Chobot, MSLS, for help with the literature search and retrieval and project coordination and Liz Wing, MA, for editorial assistance. The authors also thank the members of the stakeholder panel (Robert B. Christian, MD; Laura J. Fochtmann, MD; Martha S. Gerrity, MD, PhD, MPH; Teresa King; Marvin J. Sawyer Jr., MS; Thomas Scott Stroup, MD, MPH; Monica C. Wehby, MD; and Julie M. Zito, PhD) for their contributions.
Grant Support: By a contract from PCORI.
Potential Conflicts of Interest: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M13-2549.
Requests for Single Reprints: Gillian D. Sanders, PhD, Duke Clinical Research Institute, North Pavilion, 2400 Pratt Street, Durham, NC 27705; e-mail, firstname.lastname@example.org.
Current Author Addresses: Dr. Crowley: Durham Veterans Affairs Medical Center, Health Services Research & Development Service (152), 508 Fulton Street, Durham, NC 27705.
Drs. McCrory, Schmit, Coeytaux, and Sanders and Ms. Kendrick: Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715.
Dr. Chatterjee: Sutton Station Internal Medicine, 5832 Fayetteville Road, Suite 113, Durham, NC 27713.
Dr. Gierisch: Department of Medicine, Duke University Medical Center, Campus Box 104427 DUMC, Durham, NC 27701.
Dr. Myers: Duke University Medical Center, Box 3279, 244 Baker House, Durham, NC 27710.
Dr. Correll: Zucker Hillside Hospital, 263rd Street and 76th Avenue, Glen Oaks, NY 11004.
Author Contributions: Conception and design: M.J. Crowley, J.M. Gierisch, G.D. Sanders.
Analysis and interpretation of the data: M.J. Crowley, D.C. McCrory, R. Chatterjee, E.R. Myers, G.D. Sanders.
Drafting of the article: M.J. Crowley, D.C. McCrory, J.M. Gierisch, G.D. Sanders.
Critical revision of the article for important intellectual content: D.C. McCrory, E.R. Myers, C.U. Correll, G.D. Sanders.
Final approval of the article: M.J. Crowley, D.C. McCrory, R. Chatterjee, E.R. Myers, R.R. Coeytaux, C.U. Correll, G.D. Sanders.
Provision of study materials or patients: G.D. Sanders.
Obtaining of funding: G.D. Sanders.
Administrative, technical, or logistic support: J.M. Gierisch.
Collection and assembly of data: M.J. Crowley, D.C. McCrory, R. Chatterjee, E.R. Myers, K.M. Schmit, R.R. Coeytaux, G.D. Sanders.
Despite a paucity of high-quality evidence about benefits and harms, antipsychotic medication use among adolescents and young adults with bipolar disorder is increasing. The Patient-Centered Outcomes Research Institute tasked the Duke Evidence Synthesis Group with creating a prioritized agenda for research in this area that would incorporate the perspectives of relevant stakeholders. We identified a list of potential evidence gaps by reviewing existing literature and engaged a diverse group of 9 stakeholders to expand and refine this list. Using a forced-ranking prioritization method, stakeholders prioritized 10 of 23 potential evidence gaps as the most pressing for future research. These evidence gaps relate to 3 areas: the comparative effectiveness of intervention strategies, the effect of antipsychotics on patient-centered outcomes, and the influence of various patient characteristics on antipsychotic effectiveness. In addition to presenting these findings, we suggest appropriate study designs for addressing the stakeholder-prioritized research questions.
Overview of prioritization process.
Adapted from reference 27
ESG = Evidence Synthesis Group; PCORI = Patient-Centered Outcomes Research Institute.
Appendix Table. Final Ranking of Future Research Needs for Management Strategies for Bipolar Disorder*
Table. Study Designs Suggested for Top-Tier Future Research Needs for Management Strategies for Bipolar Disorder
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Matthew J. Crowley, Douglas C. McCrory, Ranee Chatterjee, Jennifer M. Gierisch, Evan R. Myers, Kristine M. Schmit, et al. Prioritization of Research Addressing Antipsychotics for Adolescents and Young Adults With Bipolar Disorder. Ann Intern Med. 2014;160:492–498. doi: 10.7326/M13-2549
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Published: Ann Intern Med. 2014;160(7):492-498.
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