The full report is titled “Hydroxychloroquine Effectiveness in Reducing Symptoms of Hand Osteoarthritis. A Randomized Trial.” The authors are S.R. Kingsbury, P. Tharmanathan, A. Keding, S.J. Ronaldson, A. Grainger, R.J. Wakefield, C. Arundel, F. Birrell, M. Doherty, T. Vincent, F.E. Watt, K. Dziedzic, T.W. O'Neill, N.K. Arden, D.L. Scott, J. Dickson, T. Garrood, M. Green, A. Menon, T. Sheeran, D. Torgerson, and P.G. Conaghan.
The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.
Eugene Fung, MD, FRCPC,FACR
University of Texas Southwestern Medical Center
March 26, 2018
If any use, use it in shorter term for inflammatory osteoarthritis
While the dose of Hydroxychloroquine of 200-400mg might not be adequate for Rheumatoid, we do not know what is the proper dose and this study has no information either. For any possible usage in OA is most likely chronic and then the safety of retinopathy might out-weight its benefit. For those of us who had witnessed some response in these inflammatory OA patients we might have to use it for shorter term, and use the safe dose which can be 5mg/Kg actual body weight per AAO 2016 recommendation. Beware of that formula does not address obesity which is not uncommon in OA patents. If not capped at 400mg then the usage of the old formula 6.5mg/Kg ideal body weight will be safer.
Hydroxychloroquine to Reduce Symptoms of Hand Osteoarthritis. Ann Intern Med. ;168:I–30. doi: 10.7326/P17-9055
Download citation file:
Published: Ann Intern Med. 2018;168(6):I-30.
Published at www.annals.org on 20 February 2018
Results provided by:
Copyright © 2018 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use