H. Clifford Lane, MD; Barbara E. Laughon, PhD; Judith Falloon, MD; Joseph A. Kovacs, MD; Richard T. Davey, MD; Michael A. Polis, MD, MPH; Henry Masur, MD
Secondary infections remain the leading cause of death in patients with the acquired immunodeficiency syndrome (AIDS). Dealing with the rapidly evolving spectrum of infectious problems seen in patients with AIDS requires knowledge of current therapeutic and prophylactic strategies. Through an extensive preclinical trials network supported by both industry and government, an increasing number of new agents are being identified and rapidly moved into clinical trials. Several agents are now available to treat diseases caused by Pneumocystis carinii, and corticosteroids have become a useful adjunct to antimicrobial agents in the treatment of P. carinii pneumonia. Although the treatment of toxoplasmosis remains a challenge, alternatives to sulfadiazine and pyrimethamine are now available. Mycobacterial infections, particularly with Mycobacterium tuberculosis, have become an increasing problem for patients with AIDS, and both old and new combination drug regimens are being used. Cytomegalovirus disease, until recently an untreatable problem, can now at least be partially managed with antiviral agents. The use of more complete prophylactic regimens may decrease the morbidity and mortality from opportunistic infections.
Nearly complete resolution of the contrast-enhancing lesions is seen by week 10, and this improvement was sustained through 30 weeks of therapy . Reprinted with permission from The Lancet Ltd., 1992.
Fundoscopic examination of the retina shows perivascular hemorrhage and exudate. Biopsy specimen of the lung shows characteristic cytoplasmic and intranuclear inclusions that give the “owl's eye” appearance.
. Reprinted with permission from the .
The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.
Lane HC, Laughon BE, Falloon J, Kovacs JA, Davey RT, Polis MA, et al. Recent Advances in the Management of AIDS-related Opportunistic Infections. Ann Intern Med. 1994;120:945–955. doi: 10.7326/0003-4819-120-11-199406010-00007
Download citation file:
Published: Ann Intern Med. 1994;120(11):945-955.
Copyright © 2018 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use