Derek LeRoith, MD, PhD; Renato Baserga, MD, PhD; Lee Helman, MD; Charles T. Roberts Jr., MD
The insulin-like growth factor (IGF) family of peptides, binding proteins, and receptors are important for normal human growth and development and are involved in the specialized functions of most physiologic systems. Most members of the IGF system are expressed by different cancer cells and may play an important role in the propagation of these malignancies. New therapies aimed at modulating various components of the IGF system could affect the progression and metastasis of cancer.
The amino-terminal region of the protein thought to be involved in regulating transcription is shaded, and the position of the four carboxy-terminal zinc finger domains is black. Also shown are sites of alternative splicing of the WT1 messenger RNA. The lower part of the figure shows the interaction of three of the zinc finger domains with the DNA-binding site for the WT1 protein.
IGF-II = insulin-like growth factor II. The diagram is based on data from Yun and colleagues .
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LeRoith D, Baserga R, Helman L, Roberts Jr. CT. Insulin-like Growth Factors and Cancer. Ann Intern Med. ;122:54–59. doi: 10.7326/0003-4819-122-1-199501010-00009
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Published: Ann Intern Med. 1995;122(1):54-59.
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