Derek LeRoith, MD, PhD; Renato Baserga, MD, PhD; Lee Helman, MD; Charles T. Roberts Jr., MD
The insulin-like growth factor (IGF) family of peptides, binding proteins, and receptors are important for normal human growth and development and are involved in the specialized functions of most physiologic systems. Most members of the IGF system are expressed by different cancer cells and may play an important role in the propagation of these malignancies. New therapies aimed at modulating various components of the IGF system could affect the progression and metastasis of cancer.
The amino-terminal region of the protein thought to be involved in regulating transcription is shaded, and the position of the four carboxy-terminal zinc finger domains is black. Also shown are sites of alternative splicing of the WT1 messenger RNA. The lower part of the figure shows the interaction of three of the zinc finger domains with the DNA-binding site for the WT1 protein.
IGF-II = insulin-like growth factor II. The diagram is based on data from Yun and colleagues .
The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.
Derek LeRoith, Renato Baserga, Lee Helman, Charles T. Roberts Jr.. Insulin-like Growth Factors and Cancer. Ann Intern Med. 1995;122:54–59. doi: 10.7326/0003-4819-122-1-199501010-00009
Download citation file:
Published: Ann Intern Med. 1995;122(1):54-59.
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use