Richard Simon, DSc
Requests for Single Reprints: Richard Simon, DSc, National Cancer Institute, 6130 Executive Boulevard, Room 739, Rockville, MD 20892.
Correction: Ethics of Placebo-Controlled Trials. In the editorial by Simon published in the 19 September issue (1), the source of two quotations attributed to Dr. Kenneth Rothman was identified incorrectly. These quotations were “You could torture someone for 10 minutes, and he would recover, but that doesn't mean it's a great idea … you're supposed to be acting in the best interest of the patient”, and “[placebo-controlled trials result from] a misplaced emphasis on statistical significance testing. They never know how effective any drug is because they simply ask, ‘Is it or isn't it effective? Is it significantly better than placebo? ’”. Both quotations were actually taken from the Current Clinical Issues article by Tom Reynolds that also appeared in the 19 September issue of the journal (2), rather than from the article by Rothman and Michels (3) cited in the Simon editorial.
1. Simon R. Are placebo-controlled trials ethical or needed when alternative treatment exists? [Editorial] Ann Intern Med. 2000; 133:474-5.
2. Reynolds T. The ethics of placebo-controlled trials. Ann Intern Med. 2000; 133:491-2.
3. Rothman KJ, Michels KB. The continuing unethical use of placebo controls. N Engl J Med. 1994; 331:394-8.
The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.
Simon R. Are Placebo-Controlled Clinical Trials Ethical or Needed When Alternative Treatment Exists?. Ann Intern Med. 2000;133:474–475. doi: 10.7326/0003-4819-133-6-200009190-00017
Download citation file:
Published: Ann Intern Med. 2000;133(6):474-475.
Results provided by:
Copyright © 2018 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use