Elaine M. Hylek, MD, MPH; Susan Regan, PhD; Alan S. Go, MD; Robert A. Hughes, MD; Daniel E. Singer, MD; Steven J. Skates, PhD
Steady-state warfarin dose, advanced age, and extreme elevation in international normalized ratio (INR) are risk factors for prolonged delay in return of the INR to within the therapeutic range. Decompensated congestive heart failure and active cancer greatly increase this risk.
Ann Intern Med. 2001;135(6):393-400. doi:10.7326/0003-4819-135-6-200109180-00008
G. Boudewijn C. Vasbinder, MD; Patricia J. Nelemans, MD, PhD; Alfons G.H. Kessels, MD, MSc; Abraham A. Kroon, MD, PhD; Peter W. de Leeuw, MD, PhD; Jos M.A. van Engelshoven, MD, PhD
Computed tomography angiography and gadolinium-enhanced three-dimensional magnetic resonance angiography seem to be preferred in patients referred for evaluation of renovascular hypertension. However, because few studies of these tests have been published, further research is recommended.
Ann Intern Med. 2001;135(6):401-411. doi:10.7326/0003-4819-135-6-200109180-00009
Marc Boogaerts, MD, PhD; Drew J. Winston, MD; Eric J. Bow, MD; Gary Garber, MD; Annette C. Reboli, MD; Anthony P. Schwarer, MD, FRACP; Nicolas Novitzky, MD, PhD; Angelika Boehme, MD; Elisabeth Chwetzoff, MD; Karel De Beule, RPh; and the Itraconazole Neutropenia Study Group*
Itraconazole and amphotericin B have at least equivalent efficacy when used as empirical antifungal therapy in neutropenic patients with cancer. However, itraconazole is associated with significantly less toxicity.
Ann Intern Med. 2001;135(6):412-422. doi:10.7326/0003-4819-135-6-200109180-00010
J. Taylor Hays, MD; Richard D. Hurt, MD; Nancy A. Rigotti, MD; Raymond Niaura, PhD; David Gonzales, PhD; Michael J. Durcan, PhD; David P.L. Sachs, MD; Troy D. Wolter, MS; A. Sonia Buist, MD; J. Andrew Johnston, PhD; Jonathan D. White, MS
In persons who had stopped smoking during 7 weeks of bupropion treatment, sustained-release bupropion for 12 months delayed smoking relapse and resulted in less weight gain compared with patients who received placebo.
Ann Intern Med. 2001;135(6):423-433. doi:10.7326/0003-4819-135-6-200109180-00011
Stuart Johnson, MD; Sara A. Kent, MD; Kevin J. O'Leary, MD; Michelle M. Merrigan, MS; Susan P. Sambol, BS; Lance R. Peterson, MD; Dale N. Gerding, MD
Toxin A variant strains of Clostridium difficile cause serious disease and are undetectable in clinical laboratories that use only toxin A immunoassays for C. difficile testing.
Ann Intern Med. 2001;135(6):434-438. doi:10.7326/0003-4819-135-6-200109180-00012
William H. Frishman, MD
This year's Update in Cardiology features key reports in major areas of cardiovascular medicine: prevention, unstable coronary syndromes, chronic cardiovascular disease, arrhythmias, and peripheral vascular disease.
Ann Intern Med. 2001;135(6):439-446. doi:10.7326/0003-4819-135-6-200109180-00013
Allan D. Sniderman, MD; Thea Scantlebury, BSc; Katherine Cianflone, PhD
The authors review the pathophysiology of hypertriglyceridemic hyperapoB, focusing on the changes in lipoprotein particle number and composition rather than lipoprotein lipid levels; summarize the in vitro and in vivo evidence that small, dense low-density lipoprotein (LDL) are more atherogenic than normal larger, buoyant LDL; and delineate the particularly high-risk state conferred by increased numbers of small, dense LDL.
Ann Intern Med. 2001;135(6):447-459. doi:10.7326/0003-4819-135-6-200109180-00014
Henry I. Bussey, PharmD
In this issue, Hylek and colleagues provide valuable new information that should improve the ability to manage excessive warfarin anticoagulation and reduce risk for bleeding. In the absence of more definitive data from prospective studies, this study may help physicians decide who should receive vitamin K, how much vitamin K is required, and how soon a follow-up international normalized ratio is indicated.
Ann Intern Med. 2001;135(6):460-462. doi:10.7326/0003-4819-135-6-200109180-00015
Frank Davidoff, MD; Catherine D. DeAngelis, MD, MPH; Jeffrey M. Drazen, MD; John Hoey, MD; Liselotte Højgaard, MD, DMSc; Richard Horton, FRCP; Sheldon Kotzin; Magne Nylenna; A. John P.M. Overbeke, MD, PhD; Harold C. Sox, MD; Martin B. Van Der Weyden, MD, FRACP, FRCPA; Michael S. Wilkes, MD, PhD; and The Editors
The authors of this editorial belong to the International Committee of Medical Journal Editors (ICMJE). They ask investigators to use the revised ICMJE requirements on publication ethics to guide the negotiation of contracts with corporate sponsors of research. Those contracts should give the researchers a substantial say in trial design, access to the raw data, responsibility for data analysis and interpretation, and the right to publish. The co-signers of this editorial are unlikely to publish articles when the authors did not enjoy these basic rights.
Ann Intern Med. 2001;135(6):463-466. doi:10.7326/0003-4819-135-6-200109180-00016
Brendan M. Reilly, MD
Looking back now, knowing what I know today about this place, it is easy to feel naive or stupid about what happened that night at Charlie's house. But this was 25 years ago, so I will tell you what I saw that night and how it strikes me now. But I may never know what really happened.
Ann Intern Med. 2001;135(6):467-470. doi:10.7326/0003-4819-135-6-200109180-00017
Ann Intern Med. 2001;135(6):471. doi:10.7326/0003-4819-135-6-200109180-00019
Ann Intern Med. 2001;135(6):471. doi:10.7326/0003-4819-135-6-200109180-00020
Ann Intern Med. 2001;135(6):473-476. doi:10.7326/0003-4819-135-6-200109180-00023
Rae Varcoe, MA, MB, ChB, FRACP, FRCPA
Ann Intern Med. 2001;135(6):470. doi:10.7326/0003-4819-135-6-200109180-00018
Ann Intern Med. 2001;135(6):I-37. doi:10.7326/0003-4819-135-6-200109180-00003
Ann Intern Med. 2001;135(6):I-38. doi:10.7326/0003-4819-135-6-200109180-00004
Ann Intern Med. 2001;135(6):I-39. doi:10.7326/0003-4819-135-6-200109180-00005
Ann Intern Med. 2001;135(6):I-40. doi:10.7326/0003-4819-135-6-200109180-00006
Ann Intern Med. 2001;135(6):I-41. doi:10.7326/0003-4819-135-6-200109180-00007
Judith A. O'Donnell, MD
Ann Intern Med. 2001;135(6):472. doi:10.7326/0003-4819-135-6-200109180-00021
Kenneth B. Desser, MD
Ann Intern Med. 2001;135(6):472. doi:10.7326/0003-4819-135-6-200109180-00022
Ann Intern Med. 2001;135(6):No Pagination Specified. doi:10.7326/0003-4819-135-6-200109180-00001
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