Michael Boeckh; W. Garrett Nichols; Roy F. Chemaly; Genovefa A. Papanicolaou; John R. Wingard; Hu Xie; Karen L. Syrjala; Mary E.D. Flowers; Terry Stevens-Ayers; Keith R. Jerome; Wendy Leisenring
Cytomegalovirus (CMV) disease is a complication of hematopoietic cell transplantation. In this multicenter, randomized trial, the authors compared valganciclovir prophylaxis with polymerase chain reaction–guided preemptive therapy in preventing CMV disease. They found no difference between the approaches in the occurrence of death, CMV disease, or other infections and concluded that both strategies are effective in preventing CMV disease in the setting of hematopoietic cell transplantation.
Ann Intern Med. 2015;162(1):1-10. doi:10.7326/M13-2729
Dan Yamin; Shai Gertler; Martial L. Ndeffo-Mbah; Laura A. Skrip; Mosoka Fallah; Tolbert G. Nyenswah; Frederick L. Altice; Alison P. Galvani
The current epidemic of Ebola virus disease in Western Africa is unprecedented, and there is an urgent need to control its trajectory with very limited resources. Using clinical and epidemiologic data from Liberia, researchers developed a model to estimate the effect of different approaches to epidemic control. The model suggests that isolating the most severely ill patients during the earliest days of their illness could help end the epidemic.
Ann Intern Med. 2015;162(1):11-17. doi:10.7326/M14-2255
Zhihong Liu; Haitao Zhang; Zhangsuo Liu; Changying Xing; Ping Fu; Zhaohui Ni; Jianghua Chen; Hongli Lin; Fuyou Liu; Yongcheng He; Yani He; Lining Miao; Nan Chen; Ying Li; Yong Gu; Wei Shi; Weixin Hu; Zhengzhao Liu; Hao Bao; Caihong Zeng; Minlin Zhou
The current single-drug induction regimens for lupus nephritis are associated with low rates of complete remission. This multicenter randomized trial found that a multidrug regimen targeting different components of the immune system resulted in higher rates of remission among patients with lupus nephritis. Although adverse events resulted in more patients withdrawing from the multidrug group than the standard treatment group, the overall rate of adverse events was similar.
Ann Intern Med. 2015;162(1):18-26. doi:10.7326/M14-1030
Clive Kearon; Frederick A. Spencer; Denis O'Keeffe; Sameer Parpia; Sam Schulman; Trevor Baglin; Scott M. Stevens; Scott Kaatz; Kenneth A. Bauer; James D. Douketis; Steven R. Lentz; Craig M. Kessler; Stephan Moll; Jean M. Connors; Jeffrey S. Ginsberg; Luciana Spadafora; Jim A. Julian;
Normal d-dimer levels after withdrawal of anticoagulant therapy are associated with a reduced risk for recurrence in patients with unprovoked venous thromboembolism (VTE) and may justify stopping treatment. This prospective cohort study suggests that anticoagulation should be continued indefinitely in men and that the situation is more complicated in women.
Ann Intern Med. 2015;162(1):27-34. doi:10.7326/M14-1275
J. Bruin Rugge; Christina Bougatsos; Roger Chou
This updated review for the U.S. Preventive Services Task Force assesses evidence about screening and treatment of subclinical and undiagnosed overt hypothyroidism and hyperthyroidism in adults without goiter or thyroid nodules. No study directly assessed benefits and harms of either screening or treatment of screen-detected, undiagnosed overt thyroid dysfunction. Scant data suggested that treating subclinical hypothyroidism may reduce the risk for coronary heart disease.
Ann Intern Med. 2015;162(1):35-45. doi:10.7326/M14-1456
Raveendhara R. Bannuru; Christopher H. Schmid; David M. Kent; Elizaveta E. Vaysbrot; John B. Wong; Timothy E. McAlindon
More knowledge is needed about the comparative efficacy and toxicity of treatments for knee osteoarthritis to develop rational treatment algorithms. This network metaanalysis of 137 studies found that intra-articular treatments were superior to nonsteroidal anti-inflammatory drugs and all treatments except acetaminophen showed clinically significant improvement from baseline pain.
Ann Intern Med. 2015;162(1):46-54. doi:10.7326/M14-1231
Gary S. Collins; Johannes B. Reitsma; Douglas G. Altman; Karel G.M. Moons
The TRIPOD Initiative developed a set of recommendations for reporting studies developing, validating, or updating a prediction model. Authors present a checklist of items deemed essential for transparent reporting of a prediction model. The TRIPOD Statement is best used in conjunction with the TRIPOD explanation and elaboration document.
Ann Intern Med. 2015;162(1):55-63. doi:10.7326/M14-0697
Karel G.M. Moons; Douglas G. Altman; Johannes B. Reitsma; John P.A. Ioannidis; Petra Macaskill; Ewout W. Steyerberg; Andrew J. Vickers; David F. Ransohoff; Gary S. Collins
In this TRIPOD explanation and elaboration article, authors describe and explicate each checklist item and provide published examples of good reporting.
Ann Intern Med. 2015;162(1):W1-W73. doi:10.7326/M14-0698
Frank J. Chaloupka; Jonathan Gruber; Kenneth E. Warner
The U.S. Food and Drug Administration (FDA) prepared an economic impact analysis of a proposed rule for graphic warning labels on tobacco products. This commentary discusses the analysis and finds fault with the FDA's decision to include the “lost pleasure” from tobacco use as a cost in economic impact analyses of regulations.
Ann Intern Med. 2015;162(1):64-65. doi:10.7326/M14-1910
Henry M. Wu; Jessica K. Fairley; James Steinberg; Phyllis Kozarsky
Recommendations for evaluation of patients with possible Ebola virus disease have focused on hospital emergency departments and inpatient units as the loci of care. However, patients may present to ambulatory settings. This commentary describes a dedicated, travel clinic–based program that uses existing phone triage systems, provides assessment by infectious disease experts, and ensures appropriate isolation and infection control.
Ann Intern Med. 2015;162(1):66-67. doi:10.7326/M14-2312
Mark G. Kortepeter; Philip W. Smith; Angela Hewlett; Theodore J. Cieslak
Medical centers in the United States are coming to grips with the need to prepare for care of patients with Ebola virus disease. This commentary discusses the challenges of treating these patients in a conventional setting.
Ann Intern Med. 2015;162(1):68-69. doi:10.7326/M14-2289
During the 2015 centennial year of the American College of Physicians, Annals editors will link an article in each issue with an earlier paper from our archives addressing the same disease or clinical question.
Ann Intern Med. 2015;162(1):70. doi:10.7326/M14-2654
Lisa A. Mandl; Elena Losina
In this issue, Bannuru and colleagues conducted a network meta-analysis of existing evidence to better understand the comparative efficacy and toxicity of treatments for knee osteoarthritis. The editorialists assert that innovative research models will be essential to optimize pain control for patients with knee osteoarthritis.
Ann Intern Med. 2015;162(1):71-72. doi:10.7326/M14-2636
A. Russell Localio; Catharine B. Stack
In this issue, the TRIPOD Initiative proposes an annotated checklist for transparent reporting of prediction or prognostic models. The editorialists discuss the importance of overcoming the challenges posed by multi-institutional data sources, data misclassification, measurement error, unobserved factors, and time-varying risks and treatments in such models.
Ann Intern Med. 2015;162(1):73-74. doi:10.7326/M14-2423
Ann Intern Med. 2015;162(1):75. doi:10.7326/L15-5039
Ann Intern Med. 2015;162(1):75-76. doi:10.7326/L15-5039-2
Ann Intern Med. 2015;162(1):76. doi:10.7326/L15-5039-3
Ann Intern Med. 2015;162(1):76-77. doi:10.7326/L15-5039-4
Ann Intern Med. 2015;162(1):77. doi:10.7326/L15-5040
Ann Intern Med. 2015;162(1):77. doi:10.7326/L15-5040-2
Ann Intern Med. 2015;162(1):77-78. doi:10.7326/L15-5040-3
Ann Intern Med. 2015;162(1):78. doi:10.7326/L15-5040-4
Ann Intern Med. 2015;162(1):79. doi:10.7326/L15-5040-5
Ann Intern Med. 2015;162(1):79. doi:10.7326/L15-5040-6
Ann Intern Med. 2015;162(1):80. doi:10.7326/L15-5040-7
Samuel Whittle; Rachelle Buchbinder
Ann Intern Med. 2015;162(1):ITC1. doi:10.7326/AITC201501060
Ann Intern Med. 2015;162(1):I-24. doi:10.7326/P15-9000
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