Chintan V. Dave; Aaron S. Kesselheim; Erin R. Fox; Peihua Qiu; Abraham Hartzema
Substantial price increases for specific generic drugs have recently received national attention. Some reasons for these price increases include shortages in the manufacturing supply chain and reductions in the number of generic drug manufacturers. This study used prescription claims data from commercial health plans to examine the relationship between market competition levels and changes in generic drug prices between 2008 and 2013.
Ann Intern Med. 2017;167(3):145-151. doi:10.7326/M16-1432
Gene K. Ma; Colleen M. Brensinger; Qufei Wu; James D. Lewis
Clostridium difficile infection (CDI) differs from most other infections in that it often recurs after treatment. This retrospective cohort study analyzed data on nearly 39 million commercially insured patients to evaluate whether incidence of multiply recurrent CDI (mrCDI) is increasing, determine whether any such increase is proportional to the increase in CDI, and identify risk factors for mrCDI among patients with an episode of CDI.
Ann Intern Med. 2017;167(3):152-158. doi:10.7326/M16-2733
Jason L. Vassy; Kurt D. Christensen; Erica F. Schonman; Carrie L. Blout; Jill O. Robinson; Joel B. Krier; Pamela M. Diamond; Matthew Lebo; Kalotina Machini; Danielle R. Azzariti; Dmitry Dukhovny; David W. Bates; Calum A. MacRae; Michael F. Murray; Heidi L. Rehm; Amy L. McGuire; Robert C. Green;
The clinical value of whole-genome sequencing (WGS) in asymptomatic adults is uncertain. This pilot trial describes the effects on care of adding WGS to standardized family history assessment in primary care and observed that it revealed new molecular findings of uncertain clinical utility and prompted clinical actions of unclear value.
Ann Intern Med. 2017;167(3):159-169. doi:10.7326/M17-0188
Derek K. Chu; Christopher M. Hillis; Darryl P. Leong; Sonia S. Anand; Deborah M. Siegal
This systematic review examines current evidence about the benefits and risks of antiplatelet therapy for adults with essential thrombocythemia, a disorder associated with high risk for both thrombosis and hemorrhage.
Ann Intern Med. 2017;167(3):170-180. doi:10.7326/M17-0284
Joseph W. Frank; Travis I. Lovejoy; William C. Becker; Benjamin J. Morasco; Christopher J. Koenig; Lilian Hoffecker; Hannah R. Dischinger; Steven K. Dobscha; Erin E. Krebs
This systematic review of 67 studies examines the effectiveness of 8 strategies to reduce or discontinue long-term opioid therapy in adults with chronic pain.
Ann Intern Med. 2017;167(3):181-191. doi:10.7326/M17-0598
Risa B. Burns; Gerald W. Smetana; Roscoe Brady
This Grand Rounds summarizes a discussion between 2 experts on how they would treat a 64-year-old man with depression who is reluctant to begin medication.
Ann Intern Med. 2017;167(3):192-199. doi:10.7326/M17-0966
Jean P. Hall
High-risk pools are included as a state option in the American Health Care Act recently passed by the U.S. House of Representatives. This commentary discusses what we know about the past performance of high-risk pools and why reinstituting them would be a huge step backward for U.S. health care policy.
Ann Intern Med. 2017;167(3):200-201. doi:10.7326/M17-1196
Sameer D. Saini; Akbar K. Waljee
Ma and colleagues report a retrospective cohort study to address gaps in our knowledge about mrCDI. The editorialists discuss the study's findings and limitations and why a better understanding of the epidemiology of mrCDI is a critical first step toward developing a sound strategy to address this growing problem.
Ann Intern Med. 2017;167(3):202-203. doi:10.7326/M17-1565
Teri A. Manolio
Vassy and colleagues found that adding WGS to standardized family history assessment revealed new molecular findings of uncertain clinical utility. The editorialist discusses the findings and asks whether WGS will truly improve patient outcomes.
Ann Intern Med. 2017;167(3):204-205. doi:10.7326/M17-1518
Joel S. Bennett
Chu and colleagues' systematic review examined the benefits and risks of treating patients with essential thrombocythemia with antiplatelet agents. The editorialist discusses the uncertainty the review uncovers and the need for high-quality trials to definitively address this important clinical question.
Ann Intern Med. 2017;167(3):206-207. doi:10.7326/M17-1378
Deborah Dowell; Tamara M. Haegerich
The editorialists discuss Frank and colleagues' findings and how they show that it is possible to reduce opioid use and associated risks while reducing pain and improving function and quality of life.
Ann Intern Med. 2017;167(3):208-209. doi:10.7326/M17-1402
Brian J. Hemens; Alfonso Iorio
Shekelle and colleagues describe important refinements to machine-learning software designed to reduce the need for human activity to identify relevant studies for a systematic review update. The editorialists discuss the findings and call on reviewers to evaluate these efficiency-boosting methods and reevaluate their approach to updating reviews.
Ann Intern Med. 2017;167(3):210-211. doi:10.7326/M17-1295
Ann Intern Med. 2017;167(3):212. doi:10.7326/M17-1147
Ann Intern Med. 2017;167(3):213-215. doi:10.7326/L17-0124
Ann Intern Med. 2017;167(3):215-216. doi:10.7326/L17-0102
Ann Intern Med. 2017;167(3):216-218. doi:10.7326/L16-0588
Ann Intern Med. 2017;167(3):218-219. doi:10.7326/L17-0253
Ann Intern Med. 2017;167(3):218. doi:10.7326/L17-0254
Ann Intern Med. 2017;167(3):219. doi:10.7326/L17-0255
Ann Intern Med. 2017;167(3):219-220. doi:10.7326/L17-0256
Ann Intern Med. 2017;167(3):220. doi:10.7326/L17-0257
Kristine E. Ensrud; Carolyn J. Crandall
Ann Intern Med. 2017;167(3):ITC17-ITC32. doi:10.7326/AITC201708010
Darren B. Taichman
Ann Intern Med. 2017;167(3):ED3. doi:10.7326/AFED201708010
Kartik A. Valluri
Annals Graphic Medicine brings together original graphic narratives, comics, animation/video, and other creative forms by those who provide or receive health care. They address medically relevant topics—whether they be poignant, thought-provoking, or just plain entertaining.
Ann Intern Med. 2017;167(3):W35. doi:10.7326/G17-0003
Ann Intern Med. 2017;167(3):I-20. doi:10.7326/P17-9040
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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