Maria Salgado, PhD; Mi Kwon, MD; Cristina Gálvez, MS; Jon Badiola, MD; Monique Nijhuis, PhD; Alessandra Bandera, MD, PhD; Pascual Balsalobre, PhD; Pilar Miralles, MD; Ismael Buño, PhD; Carolina Martinez-Laperche, PhD; Cristina Vilaplana, MD, PhD; Manuel Jurado, MD, PhD; Bonaventura Clotet, MD, PhD; Annemarie Wensing, MD; Javier Martinez-Picado, PhD; Jose Luis Diez-Martin, MD, PhD; for the IciStem Consortium
The multifactorial mechanisms associated with radical reductions in HIV-1 reservoirs after allogeneic hematopoietic stem cell transplant (allo-HSCT) are not fully understood. In this nested case series within an observational cohort, the authors investigate the mechanism of HIV-1 eradication associated with allo-HSCT.
Brian T. Bateman, MD, MSc; Uffe Heide-Jørgensen, MSc, PhD; Kristjana Einarsdóttir, PhD; Anders Engeland, MSc, PhD; Kari Furu, MScPharm, MPH, PhD; Mika Gissler, PhD; Sonia Hernandez-Diaz, MD, DrPH; Helle Kieler, MD, PhD; Anna-Maria Lahesmaa-Korpinen, PhD; Helen Mogun, MS; Mette Nørgaard, MD, PhD; Johan Reutfors, MD, PhD; Randi Selmer, MSc, PhD; Krista F. Huybrechts, MS, PhD; Helga Zoega, MA, PhD
β-Blockers are among the most commonly used antihypertensive medications during pregnancy, but concerns have been raised about their potential teratogenic effects. These authors analyzed data from nationwide health registries in 5 Nordic countries and the U.S. Medicaid population to examine the risk for congenital malformations in offspring of women with hypertension who were exposed to β-blockers during the first trimester of pregnancy.
Yazhou He, MD; Xue Li, MSc; Danijela Gasevic, MD, PhD; Eleanor Brunt, BMedSci; Fiona McLachlan, BSc, MBChB; Marisa Millenson, MSc; Maria Timofeeva, PhD; John P.A. Ioannidis, MD, DSc; Harry Campbell, MD; Evropi Theodoratou, MSc, PhD
This review of 112 meta-analyses of observational studies and 144 meta-analyses of randomized trials examines the validity and credibility of evidence regarding the associations between statins and non–cardiovascular disease outcomes as well as the effects of statins on these outcomes.
Min Qi Wang, PhD; Alice F. Yan, MD, PhD; Ralph V. Katz, DMD, MPH, PhD
This survey of consulting biostatisticians in the United States asked about the frequency with which they received requests for inappropriate analysis and reporting from researcher colleagues. It also asked respondents to rate the perceived severity of 18 predefined inappropriate requests.
Richard D'Aquila, MD
An allogeneic hematopoietic stem cell transplant (allo-HSCT) cured Timothy Ray Brown of HIV and cancer, adding more “known unknowns” to the HIV cure research agenda. How are latent HIV reservoirs so radically depleted by allo-HSCT? In this issue, Salgado and colleagues report on the largest number of HIV-infected patients receiving allo-HSCT with CCR5 wild-type donor cells for hematologic disease who have been studied to date and begin to address this question. The editorialist discusses the implications of the findings.
Joel G. Ray, MD, MSc
In their article, Bateman and colleagues report a study that provides reassurance regarding the safety of β-blocker use during pregnancy. The editorialist discusses the findings and their clinical implications for caring for pregnant women who have hypertension or other conditions that require the use of β-blockers.
A. Russell Localio, PhD; Catharine B. Stack, PhD; Anne R. Meibohm, PhD; Eric A. Ross, PhD; Eliseo Guallar, MD, DrPH; John B. Wong, MD; John E. Cornell, PhD; Michael E. Griswold, PhD; Steven N. Goodman, MD, MHS, PhD
The editorialists, who are all Annals statistical editors, discuss Wang and colleagues' findings and possible strategies to improve the conduct, reporting, and reproducibility of biomedical research.
Faith T. Fitzgerald, MD
William T. Clarke, MD; Joseph D. Feuerstein, MD
Giannoula S. Tansarli, MD; Eleftherios Mylonakis, MD, PhD, FIDSA
Marilyn E. Innes, MD, MSc, FRCPC, FACEP
Eric R. Bates, MD
Rahul Sharma, MD
Daniel I. Steinberg, MD
KoKo Aung, MD, MPH; Thwe Htay, MD
Jacob Korula, MD,FACP
Aaron E. Glatt, MD, FACP, FIDSA, FSHEA
Alexander A. Leung, MD, MPH; Raj S. Padwal, MD, MSc
Geno J. Merli, MD; Howard H. Weitz, MD
In this episode of the consultative medicine talk show, the Consult Guys dissect the evidence regarding whether and when surgery should be delayed because of hypertension.
Darren B. Taichman, MD, PhD
David H. Wesorick, MD; Vineet Chopra, MD, MSc
Christopher M. Petrilli, MD; Donald A. Giacherio, PhD
Although high-sensitivity assays for cardiac troponin testing can help rapidly rule out suspected acute coronary syndrome, a single measurement is generally not clinically meaningful. This commentary discusses interpretation of troponin test results when acute myocardial injury is not secondary to acute coronary syndrome.
Robert M. Centor, MD; Joel M. Topf, MD
In this episode of Annals On Call, Dr. Centor discusses diuretic resistance in patients with heart failure with Dr. Joel Topf. Listeners will gain knowledge to help make better-informed choices when prescribing diuretics to patients with heart failure.
Ron Carico, PharmD, MPH; Xinhua Zhao, PhD; Carolyn T. Thorpe, PhD, MPH; Joshua M. Thorpe, PhD, MPH; Florentina E. Sileanu, MS; John P. Cashy, PhD; Jennifer A. Hale, BA; Maria K. Mor, PhD; Thomas R. Radomski, MD, MS; Leslie R.M. Hausmann, PhD; Julie M. Donohue, PhD; Katie J. Suda, PharmD, MS; Kevin Stroupe, PhD; Joseph T. Hanlon, PharmD, MS; Chester B. Good, MD, MPH; Michael J. Fine, MD, MSc; Walid F. Gellad, MD, MPH
Receipt of overlapping prescriptions for opioids and benzodiazepines has been associated with an increased risk for overdose. A cross-sectional study compared the proportion of veterans who had overlapping opioids and benzodiazepines among those who received their prescriptions solely from VA, solely from Medicare Part D, or from both.
Jihyoun Jeon, PhD; Theodore R. Holford, PhD; David T. Levy, PhD; Eric J. Feuer, PhD; Pianpian Cao, MPH; Jamie Tam, PhD; Lauren Clarke, MSc; John Clarke, MSc; Chung Yin Kong, PhD; Rafael Meza, PhD
Although lung cancer mortality has decreased since the 1990s, lung cancer remains the leading cause of cancer death in the United States. This study used 4 simulation models of the natural history of lung cancer to project the effect of existing tobacco control efforts on lung cancer and mortality rates from 2015 to 2065.
Y. Tony Yang, ScD, LLM, MPH; Stanton Glantz, PhD
In June 2018, voters in San Francisco, California, supported implementation of a law prohibiting the sale of flavored tobacco products, including menthol cigarettes and flavored vaping liquids, despite a $12 million campaign funded almost entirely by the R.J. Reynolds Tobacco Company to oppose the law. The vote showed that with appropriate support for public health campaigns, it is possible to overcome heavily financed efforts by Big Tobacco if there is enough funding to spread the message.
Steven A. Schroeder, MD
In response to mounting concern about the use of electronic cigarettes by young people, the commissioner of the FDA recently released an action plan together with a demand that manufacturers report how they will address the problem and a threat to accelerate regulations. The author discusses the potential consequences of such actions, as well as inaction, and the potential risks and benefits involved.
Anne N. Thorndike, MD, MPH
Mirbolouk and colleagues report the prevalence of e-cigarette use by adults without a history of combustible cigarette smoking. The editorialist discusses how these findings highlight why the medical and public health communities must begin to address e-cigarette use by young adult never-smokers through screening, education, and treatment and pursue research to understand the risks of long-term exposure to e-cigarettes.
Gerard A. Silvestri, MD, MS; Matthew J. Carpenter, PhD
In this issue, Jeon and colleagues report computer models that project future lung cancer mortality among U.S. adults. The editorialists discuss the important messages about smoking, screening, and lung cancer that these projections provide.
Manuel Zorzi, MD, MSc; Cesare Hassan, MD; Giulia Capodaglio, MS; Elena Narne, MD; Anna Turrin, MS; Maddalena Baracco, MSc; Antonella Dal Cin, MSc; Annarita Fiore, MSc; Giancarla Martin, LPN; Alessandro Repici, MD; Douglas Rex, MD; Massimo Rugge, MD
We know from previous studies that screening with the fecal immunochemical test is more effective at detecting cancers in the distal than the proximal colon. The researchers who conducted this study report how this property of the test changes during 6 rounds of repeat screening.
Ilana Braun, MD; James Tulsky, MD
Despite medical marijuana's increasing use and acceptance, physician understanding of the risks and benefits of its use, guidance from medical associations, and accommodations for documentation within electronic health records are lacking. The authors discuss these gaps, why they exist, and what may be done to address them.
Gordon D. Schiff, MD; Stephen A. Martin, MD, EdM; David H. Eidelman, MD; Lynn A. Volk, MHS; Elise Ruan, BS; Christine Cassel, MD; William Galanter, MD; Mark Johnson, MD, MS; Annemarie Jutel, PhD; Kurt Kroenke, MD; Bruce L. Lambert, PhD; Joel Lexchin, MSc, MD; Sara Myers, BA; Alexa Miller, MA; Stuart Mushlin, MD; Lisa Sanders, MD; Aziz Sheikh, MD
Physicians must navigate a balance between under- and overdiagnosis, each of which may harm patients. The authors discuss core principles to help find this balance and foster a thoughtful, patient-centered, more conservative approach to diagnosis.
Chyke A. Doubeni, MD, MPH; Theodore R. Levin, MD
In their current Annals article, Zorzi and colleagues report on the yield from 6 rounds of biennial colorectal cancer screening with the fecal immunochemical test (FIT) from 2002 to 2015 in a fixed cohort of 123 347 persons. The editorialists discuss the findings, the advantages of FIT, and the need for studies to examine whether screening with FIT prevents right colon cancer deaths.
Zachary Munn, PhD; Amir Qaseem, MD, PhD, MHA; for the American College of Physicians and the Joanna Briggs Institute
Evidence-based guidelines play a pivotal role in optimizing quality of care and improving clinical outcomes for patients. In recognition of this important role, the National Guideline Clearinghouse (NGC) was created in 1998. In July 2018, the NGC went dark because of the federal government's budgetary cuts. This commentary discusses the potential negative consequences of this action.
Douglas C. Throckmorton, MD; Janet Woodcock, MD
Gomes and colleagues explore the trends and consequences of the recent and striking increase in prescribing of gabapentinoids, particularly in combination with opioids. The editorialists discuss these findings and the need to carefully investigate the consequences of combined use of all central nervous system–active drugs.
Milda R. Saunders, MD, MPH; Barbara J. Turner, MD, MSEd
Read and colleagues report on a cross-sectional 2017 survey of internists that shows that the salary gap between women and men in the medical profession has long been an unfortunate, unconscionable norm that persists in internal medicine. The editorialists discuss the findings and speculate about strategies that could promote gender equity in physician compensation.
Copyright © 2018 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use