Despite the well-established safety of outpatient treatment for pulmonary embolism in appropriately selected, low-risk patients, most continue to be hospitalized for initiation of treatment. This multicenter clinical trial tested whether delivery of a focused clinical decision support system could safely increase the number of patients with acute pulmonary embolism who are discharged to home from the emergency department.
Recent studies of state-level data suggest that the United States is experiencing a transition from heart disease to cancer as the leading cause of death. This analysis provides data on this “new epidemiologic transition” at the county level and by socioeconomic characteristics.
In their article, Vinson and colleagues add to mounting evidence for the safety of home treatment of selected patients with pulmonary embolism. The editorialists discuss the findings and speculate why few stable patients receive home treatment despite evidence of its safety in selected patients and cost-effectiveness.
Silvia Stringhini, PhD; Idris Guessous, MD, PhD
A combination of increased prevention and improved medical treatment of cardiovascular disease has allowed cancer to gradually replace heart disease as the leading cause of death in high-income countries over the past decade. The study by Hastings and colleagues in this issue provides a lens for interpreting the population dynamics related to the epidemiologic transition. The editorialists discuss the findings from a social epidemiology perspective.
Anne N. Thorndike, MD, MPH
Mirbolouk and colleagues report the prevalence of e-cigarette use by adults without a history of combustible cigarette smoking. The editorialist discusses how these findings highlight why the medical and public health communities must begin to address e-cigarette use by young adult never-smokers through screening, education, and treatment and pursue research to understand the risks of long-term exposure to e-cigarettes.
Abigail Fraser, BA, MA, MPH, PhD
In this issue, Stuart and colleagues, using data from the Nurses' Health Study II, report associations between a history of a first pregnancy complicated by a hypertensive disorder of pregnancy and physician-diagnosed hypertension, hypercholesterolemia, and type 2 diabetes over the course of 3 decades after pregnancy. The editorialist discusses the findings and the need to invest in research on this topic to reduce the burden of cardiovascular disease in women.
Irl B. Hirsch, MD; Jay S. Skyler, MD
This commentary was selected for publication from among several submitted in response to a call for readers' perspectives on treatment targets for type 2 diabetes.
Brian V. Burke, MD; Sandra Hedin, PharmD
D.R. Bailey Miles, MD
David C. Aron, MD, MS; Paul R. Conlin, MD; Leonard Pogach, MD, MBA
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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