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Therapy-Related Acute Myelogenous Leukemia in a Hydroxyurea-Treated Patient With Sickle Cell Anemia

James G. Taylor, MD; Deepika S. Darbari, MD; Irina Maric, MD; Zachariah McIver, MD; and Diane C. Arthur, MD
[+] Article, Author, and Disclosure Information

From National Institutes of Health, Bethesda, MD 20892-1476.

Potential Conflicts of Interest:Patent pending: 12/423,750 (U.S. Application); Stock/stock options: Amgen, AstraZeneca, Bristol-Myers Squibb, Fidelity Select Biotech, General Electric, Monsanto, ATT, Chevron Corporation, Citigroup, Comcast, Entergy, Exxon Corporation, Fidelity Select Energy, Hewlett Packard, Intel, IBM, Juniper Networks, Marine Products Corp., Motorola, Proctor and Gamble, Rollins, RPC, Sysco, Tokeville Gold Fund, Traveller Companies.

Ann Intern Med. 2011;155(10):722-724. doi:10.7326/0003-4819-155-10-201111150-00024
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Case synopsis of AML, with images from peripheral blood and bone marrow.

AML = acute myelogenous leukemia; ANC = absolute neutrophil count; HbF = fetal hemoglobin; MCV = mean corpuscular volume; MPO = myeloperoxidase. A. Timeline with events listed. Graphs illustrate ANC, HbF level, MCV, and hydroxyurea dose over 6 years. The red triangles indicate red blood cell transfusions (E = exchange; S = simple), and the blue squares indicate interruption of hydroxyurea therapy. Time from the start of hydroxyurea therapy to diagnosis was 50 months. B. Images from peripheral blood, marrow, and immunocytochemistry at diagnosis.

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