0
Summaries for Patients |

Vitamin D Levels and Risk for Major Clinical Disease Events FREE

[+] Article and Author Information

The full report is titled “Serum 25-Hydroxyvitamin D Concentration and Risk for Major Clinical Disease Events in a Community-Based Population of Older Adults. A Cohort Study.” It is in the 1 May 2012 issue of Annals of Internal Medicine (volume 156, pages 627-634). The authors are I.H. de Boer, G. Levin, C. Robinson-Cohen, M.L. Biggs, A.N. Hoofnagle, D.S. Siscovick, and B. Kestenbaum.


Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.

Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians.


Ann Intern Med. 2012;156(9):I-36. doi:10.7326/0003-4819-156-9-201205010-00001
Text Size: A A A

What is the problem and what is known about it so far?

Although we know that vitamin D deficiency causes some medical problems and investigators are studying it as a possible cause of others, experts disagree about how to define deficiency. Most experts believe that vitamin D deficiency begins when blood levels get low enough to change how fast the body creates and breaks down bone, which we evaluate by measuring blood constituents that are produced and used during bone remodeling.

Why did the researchers do this particular study?

To evaluate the relationship of vitamin D levels with clinical outcomes that may be related to vitamin D deficiency.

Who was studied?

More than 1500 white, elderly persons who were living in 4 U.S. communities.

How was the study done?

The researchers took blood samples from study participants at the beginning of the study and then followed them to see whether they developed any of the more important clinical outcomes that may be related to vitamin D deficiency (for example, hip fracture). They used blood levels of a precursor to vitamin D (known as 25-hydroxyvitamin D) to represent vitamin D levels.

What did the researchers find?

The outcomes they were looking for began to occur more often as blood levels of 25-hydroxyvitamin D decreased from higher than 20 ng/mL to lower than 20 ng/mL.

What were the limitations of the study?

Observational studies such as this one cannot establish cause and effect, so additional studies will be necessary to resolve these discrepancies.

What are the implications of the study?

Most professional societies and expert panels recommend that 30 ng/mL be considered the threshold level below which vitamin D deficiency begins. This study found a lower threshold, which is the same level recently recommended by the Institute of Medicine.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)